%0 Journal Article %1 Krach2005 %A Krach, Linda E %A Kriel, Robert L %A Gilmartin, Richard C %A Swift, Dale M %A Storrs, Bruce B %A Abbott, Rick %A Ward, John D %A Bloom, Karen K %A Brooks, William H %A Madsen, Joseph R %A McLaughlin, John F %A Nadell, Joseph M %D 2005 %J Pediatr Rehabil %K Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lower Extremity; Moto; Muscle Contraction; Relaxants, Central; Spasticity; Patient Satisfaction; Physical Endurance; Posture; Prospective r Activity %N 3 %P 207--213 %R 10.1080/13638490400021479 %T GMFM 1 year after continuous intrathecal baclofen infusion. %U http://dx.doi.org/10.1080/13638490400021479 %V 8 %X The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.

@article{Krach2005, abstract = {The purpose of this study was to assess whether there is an improvement in motor function in persons with cerebral palsy (CP) who have had a reduction of muscle tone by continuous intrathecal baclofen infusion. This was a prospective, open label, non-blinded case series without a control group, conducted at multiple centres. There were 31 subjects, aged 4-29 years. All had a pre-treatment mean lower extremity Ashworth scores of >or= 3 and a significant reduction in tone after a bolus injection of intrathecal baclofen (ITB) and received an implanted pump for continuous delivery of ITB. Motor function was assessed by the Gross Motor Function Measure (GMFM) prior to and 1 year following pump implantation. Significant improvement (p < 0.05) in mean GMFM scores was seen in subjects < 8 years (mean change 4.1) and in those from 8-18 years (mean change 3.7) and in subjects with CP Classes 2 and 5 (mean changes 6.2 and 2.9). There was a statistically significant decrease (p < 0.05) in Ashworth scores in CP classes 2-5. Subjects or their caregivers that completed a survey about perceived changes stated that motor control, positioning and endurance improved.}, added-at = {2014-07-19T20:39:24.000+0200}, author = {Krach, Linda E and Kriel, Robert L and Gilmartin, Richard C and Swift, Dale M and Storrs, Bruce B and Abbott, Rick and Ward, John D and Bloom, Karen K and Brooks, William H and Madsen, Joseph R and McLaughlin, John F and Nadell, Joseph M}, biburl = {https://www.bibsonomy.org/bibtex/2b68edc845a2cdaad02fd791d1b632272/ar0berts}, doi = {10.1080/13638490400021479}, groups = {public}, interhash = {642cdd940fd5cf778fb28eb791966a8c}, intrahash = {b68edc845a2cdaad02fd791d1b632272}, journal = {Pediatr Rehabil}, keywords = {Adolescent; Adult; Baclofen; Cerebral Palsy; Child; Child, Preschool; Follow-Up Studies; Humans; Infusion Pumps, Implantable; Injections, Spinal; Lower Extremity; Moto; Muscle Contraction; Relaxants, Central; Spasticity; Patient Satisfaction; Physical Endurance; Posture; Prospective r Activity}, number = 3, pages = {207--213}, pii = {RD9W21W2PHWKEEU6}, pmid = {16087555}, timestamp = {2014-07-19T20:39:24.000+0200}, title = {GMFM 1 year after continuous intrathecal baclofen infusion.}, url = {http://dx.doi.org/10.1080/13638490400021479}, username = {ar0berts}, volume = 8, year = 2005 }