Abstract
Establishment and maintenance of the blood system relies on self-renewing
hematopoietic stem cells (HSCs) that normally reside in small numbers
in the bone marrow niche of adult mammals. This Review describes
the developmental origins of HSCs and the molecular mechanisms that
regulate lineage-specific differentiation. Studies of hematopoiesis
provide critical insights of general relevance to other areas of
stem cell biology including the role of cellular interactions in
development and tissue homeostasis, lineage programming and reprogramming
by transcription factors, and stage- and age-specific differences
in cellular phenotypes.
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