%0 Journal Article %1 Zusterzeel.2008 %A Zusterzeel, P. L. %A Span, P. N. %A Dijksterhuis, M. G. %A Thomas, C. M. %A Sweep, F. C. %A Massuger, L. F. %D 2008 %J J.Cancer Res.Clin.Oncol. %K methods %T Serum vascular endothelial growth factor: a prognostic factor in cervical cancer %U PM:18626660 %X PURPOSE: To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS: VEGF was measured using ELISA in the largest patient group (n = 167) to date. REULTS: Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tumors larger than 2 cm) (P = 0.03), and the presence of vascular space invasion (P = 0.05). Serum VEGF was associated with disease free and overall survival DFS: Hazard Ratio (HR) = 2.61; 95% CI 1.32-5.17; P = 0.006; for OS: HR = 2.09; 95% CI 1.54-2.84; P < 0.001, respectively. In multivariate Cox regression serum VEGF retained its prognostic value for DFS (HR = 2.10, P = 0.03) and OS (HR = 1.92, P = 0.04). CONCLUSIONS: Serum VEGF levels correlate with more advanced and more aggressive disease in cervical cancer and may be a useful prognostic factor in patients with cervical cancer

@article{Zusterzeel.2008, abstract = {PURPOSE: To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. METHODS: VEGF was measured using ELISA in the largest patient group (n = 167) to date. REULTS: Serum VEGF was significantly higher in advanced tumor stage (P = 0.01), large tumor size (tumors larger than 2 cm) (P = 0.03), and the presence of vascular space invasion (P = 0.05). Serum VEGF was associated with disease free and overall survival [DFS: Hazard Ratio (HR) = 2.61; 95% CI 1.32-5.17; P = 0.006; for OS: HR = 2.09; 95% CI 1.54-2.84; P < 0.001, respectively]. In multivariate Cox regression serum VEGF retained its prognostic value for DFS (HR = 2.10, P = 0.03) and OS (HR = 1.92, P = 0.04). CONCLUSIONS: Serum VEGF levels correlate with more advanced and more aggressive disease in cervical cancer and may be a useful prognostic factor in patients with cervical cancer}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Zusterzeel, P. L. and Span, P. N. and Dijksterhuis, M. G. and Thomas, C. M. and Sweep, F. C. and Massuger, L. F.}, biburl = {https://www.bibsonomy.org/bibtex/2d8e2bb1f7f580ae921ae92f0b2e929e9/kanefendt}, interhash = {6ce4ae32e2e8a7ab6d7424bb5f8259a2}, intrahash = {d8e2bb1f7f580ae921ae92f0b2e929e9}, journal = {J.Cancer Res.Clin.Oncol.}, keywords = {methods}, timestamp = {2010-02-05T11:28:50.000+0100}, title = {Serum vascular endothelial growth factor: a prognostic factor in cervical cancer}, url = {PM:18626660}, year = 2008 }