%0 Book Section %1 statphys23_1047 %A Morelli, L.G. %A Julicher, F. %B Abstract Book of the XXIII IUPAP International Conference on Statistical Physics %C Genova, Italy %D 2007 %E Pietronero, Luciano %E Loreto, Vittorio %E Zapperi, Stefano %K amplification amplitude delays feedback genetic noise oscillators phase statphys23 stochastic topic-10 %T Stochastic description of time delayed feedback oscillators %U http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=1047 %X Many cellular processes are regulated or driven by genetic oscillators, as in the case of circadian clocks, the cell cycle, and patterning developing vertebrate embryos. Due to the stochastic nature of gene expression, the period of such oscillations is subject to fluctuations. The precision of the oscillator can be characterized by the quality factor. We study the precision of genetic oscillators in a generic stochastic feedback system. We include the effects of amplification noise, arising for example from bursts of transcription and translation. We show that high quality is possible for certain parameter ranges even when the number of molecules is low and amplitude fluctuations are large.

@incollection{statphys23_1047, abstract = {Many cellular processes are regulated or driven by genetic oscillators, as in the case of circadian clocks, the cell cycle, and patterning developing vertebrate embryos. Due to the stochastic nature of gene expression, the period of such oscillations is subject to fluctuations. The precision of the oscillator can be characterized by the quality factor. We study the precision of genetic oscillators in a generic stochastic feedback system. We include the effects of amplification noise, arising for example from bursts of transcription and translation. We show that high quality is possible for certain parameter ranges even when the number of molecules is low and amplitude fluctuations are large.}, added-at = {2007-06-20T10:16:09.000+0200}, address = {Genova, Italy}, author = {Morelli, L.G. and Julicher, F.}, biburl = {https://www.bibsonomy.org/bibtex/2978e1bd3676212fef9a48fa258ab2f3a/statphys23}, booktitle = {Abstract Book of the XXIII IUPAP International Conference on Statistical Physics}, editor = {Pietronero, Luciano and Loreto, Vittorio and Zapperi, Stefano}, interhash = {6e3bafa73f6498632afacb222635ad1d}, intrahash = {978e1bd3676212fef9a48fa258ab2f3a}, keywords = {amplification amplitude delays feedback genetic noise oscillators phase statphys23 stochastic topic-10}, month = {9-13 July}, timestamp = {2007-06-20T10:16:37.000+0200}, title = {Stochastic description of time delayed feedback oscillators}, url = {http://st23.statphys23.org/webservices/abstract/preview_pop.php?ID_PAPER=1047}, year = 2007 }