%0 Journal Article %1 Rizz_2003_8619 %A Rizzuto, Rosario %A Pinton, Paolo %A Ferrari, Davide %A Chami, Mounia %A Szabadkai, Gy�rgy %A Magalhães, Paulo J %A Virgilio, Francesco Di %A Pozzan, Tullio %D 2003 %J Oncogene %K 14634623 ATPase, Animals, Apoptosis, C, Calcium Calcium, Cation Endopeptidases, Endoplasmic Gov't, Homeostasis, Humans, Kinase Mitochondria, Non-U.S. Protein Proteins Proteins, Proto-Oncogene Research Reticulum, Signal Signaling, Support, Transduction, Transport c-bcl-2, {C}a$^{2+}$-Transporting %N 53 %P 8619--8627 %R 10.1038/sj.onc.1207105 %T Calcium and apoptosis: facts and hypotheses. %U http://dx.doi.org/10.1038/sj.onc.1207105 %V 22 %X Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few years the role of calcium in the signaling of apoptosis has been extensively investigated. In this review, we will summarize the current knowledge, focusing on (i) the effect of the proteins of the Bcl-2 family on ER Ca$^2+$ levels, (ii) the action of the proteolytic enzymes of apoptosis on the Ca$^2+$ signaling machinery, (iii) the ensuing alterations on the signaling patterns of extracellular stimuli, and (iv) the intracellular targets of 'apoptotic' Ca$^2+$ signals, with special emphasis on the mitochondria and cytosolic Ca$^2+$-dependent enzymes.

@article{Rizz_2003_8619, abstract = {Although longstanding experimental evidence has associated alterations of calcium homeostasis to cell death, only in the past few years the role of calcium in the signaling of apoptosis has been extensively investigated. In this review, we will summarize the current knowledge, focusing on (i) the effect of the proteins of the Bcl-2 family on ER {C}a$^{2+}$ levels, (ii) the action of the proteolytic enzymes of apoptosis on the {C}a$^{2+}$ signaling machinery, (iii) the ensuing alterations on the signaling patterns of extracellular stimuli, and (iv) the intracellular targets of 'apoptotic' {C}a$^{2+}$ signals, with special emphasis on the mitochondria and cytosolic {C}a$^{2+}$-dependent enzymes.}, added-at = {2009-06-03T11:20:58.000+0200}, author = {Rizzuto, Rosario and Pinton, Paolo and Ferrari, Davide and Chami, Mounia and Szabadkai, Gy�rgy and Magalhães, Paulo J and Virgilio, Francesco Di and Pozzan, Tullio}, biburl = {https://www.bibsonomy.org/bibtex/20b36da44ec2a3d7753e4c398afd60d15/hake}, description = {The whole bibliography file I use.}, doi = {10.1038/sj.onc.1207105}, file = {Rizz_2003_8619.pdf:Rizz_2003_8619.pdf:PDF}, interhash = {70340c8ba83b4c376382476c9e9a52e8}, intrahash = {0b36da44ec2a3d7753e4c398afd60d15}, journal = {Oncogene}, keywords = {14634623 ATPase, Animals, Apoptosis, C, Calcium Calcium, Cation Endopeptidases, Endoplasmic Gov't, Homeostasis, Humans, Kinase Mitochondria, Non-U.S. Protein Proteins Proteins, Proto-Oncogene Research Reticulum, Signal Signaling, Support, Transduction, Transport c-bcl-2, {C}a$^{2+}$-Transporting}, month = Nov, number = 53, pages = {8619--8627}, pii = {1207105}, pmid = {14634623}, timestamp = {2009-06-03T11:21:27.000+0200}, title = {Calcium and apoptosis: facts and hypotheses.}, url = {http://dx.doi.org/10.1038/sj.onc.1207105}, volume = 22, year = 2003 }