%0 Journal Article %1 Carati:2011:Pharmacol-Biochem-Behav:21334368 %A Carati, C %A Schenk, S %D 2011 %J Pharmacol Biochem Behav %K ToDo %N 3 %P 449-454 %R 10.1016/j.pbb.2011.02.010 %T Role of dopamine D1- and D2-like receptor mechanisms in drug-seeking following methamphetamine self-administration in rats %U http://www.ncbi.nlm.nih.gov/pubmed/21334368 %V 98 %X It has been suggested that dopaminergic mechanisms mediate relapse to drug-seeking behavior and both D1- and D2-like receptor mechanisms have been implicated. In contrast to self-administration of other drugs, there is a relative paucity of studies that has examined the pharmacological basis of methamphetamine (MA) seeking. Accordingly, the present study used an animal model of drug-seeking to determine the role of D1- and D2-like receptor mechanisms in relapse to MA abuse. Rats were trained to self-administer MA, and then responding was extinguished by replacing the MA solution with vehicle. Experimenter-administered injections of MA or the dopamine uptake inhibitor, GBR 12909, reinstated extinguished responding in a dose-dependent manner. The D1-like antagonist, SCH 23390 attenuated drug-seeking but the D2-like antagonist, eticlopride, was ineffective. The results suggest that MA-seeking is predominantly mediated by DA D1-like receptor mechanisms. These findings are in contrast to the literature on drug-seeking following self-administration of other drugs, and suggest that relapse to different drugs of abuse may rely upon different DA receptor mechanisms.

@article{Carati:2011:Pharmacol-Biochem-Behav:21334368, abstract = {It has been suggested that dopaminergic mechanisms mediate relapse to drug-seeking behavior and both D1- and D2-like receptor mechanisms have been implicated. In contrast to self-administration of other drugs, there is a relative paucity of studies that has examined the pharmacological basis of methamphetamine (MA) seeking. Accordingly, the present study used an animal model of drug-seeking to determine the role of D1- and D2-like receptor mechanisms in relapse to MA abuse. Rats were trained to self-administer MA, and then responding was extinguished by replacing the MA solution with vehicle. Experimenter-administered injections of MA or the dopamine uptake inhibitor, GBR 12909, reinstated extinguished responding in a dose-dependent manner. The D1-like antagonist, SCH 23390 attenuated drug-seeking but the D2-like antagonist, eticlopride, was ineffective. The results suggest that MA-seeking is predominantly mediated by DA D1-like receptor mechanisms. These findings are in contrast to the literature on drug-seeking following self-administration of other drugs, and suggest that relapse to different drugs of abuse may rely upon different DA receptor mechanisms.}, added-at = {2013-05-09T17:30:19.000+0200}, author = {Carati, C and Schenk, S}, biburl = {https://www.bibsonomy.org/bibtex/24c0a3432c80b8990a5e41e1e20f1dac9/kilianjay}, description = {Role of dopamine D1- and D2-like rec... [Pharmacol Biochem Behav. 2011] - PubMed - NCBI}, doi = {10.1016/j.pbb.2011.02.010}, interhash = {727e1d4298652986413d9c703b428377}, intrahash = {4c0a3432c80b8990a5e41e1e20f1dac9}, journal = {Pharmacol Biochem Behav}, keywords = {ToDo}, month = may, number = 3, pages = {449-454}, pmid = {21334368}, timestamp = {2013-05-09T17:30:19.000+0200}, title = {Role of dopamine D1- and D2-like receptor mechanisms in drug-seeking following methamphetamine self-administration in rats}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21334368}, volume = 98, year = 2011 }