%0 Journal Article %1 whitlock2008evolutionary %A Whitlock, Michael C. %D 2008 %I Blackwell Publishing Ltd %J Molecular Ecology %K F_ST Q_ST methods quantitative_genetics spatial_structure %N 8 %P 1885--1896 %R 10.1111/j.1365-294X.2008.03712.x %T Evolutionary inference from QST %U http://dx.doi.org/10.1111/j.1365-294X.2008.03712.x %V 17 %X Q ST is a commonly used metric of the degree of genetic differentiation among populations displayed by quantitative traits. Typically, QST is compared to FST measured on putatively neutral loci; if QST=FST, this is taken as evidence of spatially heterogeneous and diversifying selection. This paper reviews the uses, assumptions and statistics of QST and FST comparisons. Unfortunately, QST/FST comparisons are statistically challenging. For a single trait, QST must be compared not to the mean FST but to the distribution of FST values. The sources of biases and sampling error for QST are reviewed, and a new method for comparing QST and FST is suggested. Simulation results suggest that the distribution of neutral FST and QST values are little affected by various deviations from the island model. Consequently, the distributions of QST and FST are well approximated by the Lewontin–Krakauer prediction, even with realistic deviations from the island-model assumptions.

@article{whitlock2008evolutionary, abstract = {Q ST is a commonly used metric of the degree of genetic differentiation among populations displayed by quantitative traits. Typically, QST is compared to FST measured on putatively neutral loci; if QST=FST, this is taken as evidence of spatially heterogeneous and diversifying selection. This paper reviews the uses, assumptions and statistics of QST and FST comparisons. Unfortunately, QST/FST comparisons are statistically challenging. For a single trait, QST must be compared not to the mean FST but to the distribution of FST values. The sources of biases and sampling error for QST are reviewed, and a new method for comparing QST and FST is suggested. Simulation results suggest that the distribution of neutral FST and QST values are little affected by various deviations from the island model. Consequently, the distributions of QST and FST are well approximated by the Lewontin–Krakauer prediction, even with realistic deviations from the island-model assumptions.}, added-at = {2017-01-22T07:10:31.000+0100}, author = {Whitlock, Michael C.}, biburl = {https://www.bibsonomy.org/bibtex/29d61be84bfdbd35f08d0ea0caac87836/peter.ralph}, doi = {10.1111/j.1365-294X.2008.03712.x}, interhash = {739b5f528bc52aad1b42b8d3e5e0d226}, intrahash = {9d61be84bfdbd35f08d0ea0caac87836}, issn = {1365-294X}, journal = {Molecular Ecology}, keywords = {F_ST Q_ST methods quantitative_genetics spatial_structure}, number = 8, pages = {1885--1896}, publisher = {Blackwell Publishing Ltd}, timestamp = {2017-01-22T07:10:31.000+0100}, title = {Evolutionary inference from {QST}}, url = {http://dx.doi.org/10.1111/j.1365-294X.2008.03712.x}, volume = 17, year = 2008 }