%0 Journal Article %1 Naeye2005 %A Naeye, Richard L %A Shaffer, Michele L %D 2005 %J J Perinatol %K Brain Damage, Chronic; Ischemia; Cerebral Palsy; Humans; Infant, Newborn; Lymphocyte Count; Platelet Count %N 10 %P 664--668 %R 10.1038/sj.jp.7211367 %T Postnatal laboratory timers of antenatal hypoxemic-ischemic brain damage. %U http://dx.doi.org/10.1038/sj.jp.7211367 %V 25 %X OBJECTIVE: Markers were sought to identify the antenatal starting times and rates at which brain damage advanced in children with hypoxemic-ischemic cerebral palsy. STUDY DESIGN: Fetal bradycardia's onset marked the damage's start. Using this baseline, the following were tested as additional timers of the damage's onset: serial blood counts of neonates' normoblasts, platelets, lymphocytes,differences at birth between base excess values in umbilical arterial and venous bloods,brain damage patterns. RESULTS: Each timer had a broad antenatal time frame within which it could identify specific damage starting times. The broad time frames are as follows: Blood lymphocyte counts: 0.45 to 13.8 hours before birth, blood normoblast counts: 0.45 to 55.0 hours before birth, blood platelet counts: 0.5 to >72 hours before birth.Brain damage patterns: 0.4 to >0.7 hour before birth. Hyperventilating and hyperoxygenating neonates greatly accelerated the damage's advance. CONCLUSIONS: Commonly obtained laboratory values and brain images can identify when such brain damage began and the rate at which it advanced.

@article{Naeye2005, abstract = {OBJECTIVE: Markers were sought to identify the antenatal starting times and rates at which brain damage advanced in children with hypoxemic-ischemic cerebral palsy. STUDY DESIGN: Fetal bradycardia's onset marked the damage's start. Using this baseline, the following were tested as additional timers of the damage's onset: serial blood counts of neonates' normoblasts, platelets, lymphocytes,differences at birth between base excess values in umbilical arterial and venous bloods,brain damage patterns. RESULTS: Each timer had a broad antenatal time frame within which it could identify specific damage starting times. The broad time frames are as follows: Blood lymphocyte counts: 0.45 to 13.8 hours before birth, blood normoblast counts: 0.45 to 55.0 hours before birth, blood platelet counts: 0.5 to >72 hours before birth.Brain damage patterns: 0.4 to >0.7 hour before birth. Hyperventilating and hyperoxygenating neonates greatly accelerated the damage's advance. CONCLUSIONS: Commonly obtained laboratory values and brain images can identify when such brain damage began and the rate at which it advanced.}, added-at = {2014-07-19T20:49:55.000+0200}, author = {Naeye, Richard L and Shaffer, Michele L}, biburl = {https://www.bibsonomy.org/bibtex/20eb84890de14b9ac9d259b38303574b2/ar0berts}, doi = {10.1038/sj.jp.7211367}, groups = {public}, interhash = {7971adfe8308da1d4ca839a3673a22c3}, intrahash = {0eb84890de14b9ac9d259b38303574b2}, journal = {J Perinatol}, keywords = {Brain Damage, Chronic; Ischemia; Cerebral Palsy; Humans; Infant, Newborn; Lymphocyte Count; Platelet Count}, month = Oct, number = 10, pages = {664--668}, pii = {7211367}, pmid = {16079907}, timestamp = {2014-07-19T20:49:55.000+0200}, title = {Postnatal laboratory timers of antenatal hypoxemic-ischemic brain damage.}, url = {http://dx.doi.org/10.1038/sj.jp.7211367}, username = {ar0berts}, volume = 25, year = 2005 }