%0 Journal Article %1 Goldstein2002b %A Goldstein, Ellie J C. %D 2002 %J Clin Infect Dis %K drug drugresistance quinolone carbapenem metronidazole %N Suppl 1 %P S106--S111 %R 10.1086/341930 %T Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents. %U http://dx.doi.org/10.1086/341930 %V 35 %X Intra-abdominal infections are biphasic, synergistic processes with early peritonitis and bacteremia due to aerobes and a later abscess component due to anaerobes. Although Bacteroides fragilis is the most commonly recognized pathogen, other anaerobes, including other members of the B. fragilis-group species, are major components of infection. Anaerobic bacteremia is often associated with an intra-abdominal source. New antimicrobial agents with anaerobic activity are in various stages of development for the therapy of intra-abdominal infections. The in vitro activity and the currently available sparse clinical data are reviewed for a new carbapenem (ertapenem), several fluoroquinolones (trovafloxacin, moxifloxacin, and gemifloxacin), and a desfluoroquinolone (BMS-284756).

@article{Goldstein2002b, abstract = {Intra-abdominal infections are biphasic, synergistic processes with early peritonitis and bacteremia due to aerobes and a later abscess component due to anaerobes. Although Bacteroides fragilis is the most commonly recognized pathogen, other anaerobes, including other members of the B. fragilis-group species, are major components of infection. Anaerobic bacteremia is often associated with an intra-abdominal source. New antimicrobial agents with anaerobic activity are in various stages of development for the therapy of intra-abdominal infections. The in vitro activity and the currently available sparse clinical data are reviewed for a new carbapenem (ertapenem), several fluoroquinolones (trovafloxacin, moxifloxacin, and gemifloxacin), and a desfluoroquinolone (BMS-284756).}, added-at = {2012-12-19T02:16:42.000+0100}, author = {Goldstein, Ellie J C.}, biburl = {https://www.bibsonomy.org/bibtex/2f5575846c84e141e7fd83db569db2f98/aorchid}, description = {review of bacteriology of infections in abdomen, a bit older}, doi = {10.1086/341930}, groups = {public}, institution = {R. M. Alden Research Laboratory, Santa Monica, CA, USA; and UCLA School of Medicine, Los Angeles, CA, USA. EJCGMD@aol.com}, interhash = {7edcfc66f681ffb5afc5722b6a5bea9a}, intrahash = {f5575846c84e141e7fd83db569db2f98}, journal = {Clin Infect Dis}, keywords = {drug drugresistance quinolone carbapenem metronidazole}, language = {eng}, medline-pst = {ppublish}, month = Sep, number = {Suppl 1}, pages = {S106--S111}, pii = {CID020085}, pmid = {12173118}, timestamp = {2012-12-19T02:16:42.000+0100}, title = {Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents.}, url = {http://dx.doi.org/10.1086/341930}, username = {aorchid}, volume = 35, year = 2002 }