Article,

Blocking effect of brain extract on lysergic acid diethylamide reaction in Siamese fighting fish

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Science, (1957)

Abstract

Üntil LSD-25 was added to distilled water, none of the fish showed the typical nose up-tail down position except as a normal movement. Fifteen minutes after the LSD-25 was added to the five vessels, all the fish in the LSD-25 control showed the nose up-tail down position and continued to do so throughout the experiment. Essentially similar results were obtained in the bottle containing 0.02 mg of crude brain extract per milliliter. In the bottle containing 2 mg of brain extract per milliliter by contrast, not only was the initial excitatory phase absent, but there was also a lag, with one fish showing the nose up-tail down behavior at 45 minutes and only four fish showing this behavior at 1 hour." (PsycINFO Database Record (c) 2004 APA, all rights reserved)

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