%0 Journal Article %1 WOS:000339820500007 %A Abdon, Ana Paula Vasconcellos %A Vasconcelos, Renata Prado %A Castro, Carolina Araujo %A Guedes, Marjorie Moreira %A da Tome, Adriana Rocha %A Cardoso, Andre Luiz Herzog %A de Santiago, Thiago Melo %A Rebelo, Luciana Magalhaes %A de Moreira, Renato Azevedo %A de Oliveira Monteiro-Moreira, Ana Cristina %A Campos, Adriana Rolim %C VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS %D 2014 %I SPRINGER %J INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS %K Ethanol-induced Frutalin; Gastroprotective; Microscopic analysis} gastric incisa; injury; {Artocarpus %N 3 %P 325-332 %R 10.1007/s10989-014-9398-8 %T Ethanol-Induced Gastric Injury: Microscopic Analysis of the Protective Effect of Frutalin %V 20 %X Obtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanol-induced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.

@article{WOS:000339820500007, abstract = {Obtained from breadfruit seeds (Artocarpus incisa), frutalin (FTL) has a range of important pharmacological properties. FTL activates and modulates lymphocytes and neutrophils and possesses gastroprotective effects. The purpose of this study was to evaluate the ability of FTL to protect the gastric mucosa of mice submitted to ethanol-induced gastric injury. The gastroprotective effect of frutalina was evaluated using a murine model of ethanol-induced gastric injury. Damage of the gastric mucosa was assessed morphologically by light, scanning electron and atomic force microscopy. Lymphocyte infiltration, necrosis, disruption of the mucosal structures and epithelial desquamation were observed in the control group. In the group pretreated with frutalina at 0.5 mg/kg, gastroprotection, reduced tissue damage and preserved submucosal and mucosal structures were observed. In conclusion, FTL displayed gastroprotective activity against ethanol-induced gastric injury, preventing the formation of gastric ulcer and reducing epithelial desquamation, glandular damage, mucosal necrosis and infiltration. The observed effects appear to be due to mechanisms previously described for frutalin.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS}, author = {Abdon, Ana Paula Vasconcellos and Vasconcelos, Renata Prado and Castro, Carolina Araujo and Guedes, Marjorie Moreira and da Tome, Adriana Rocha and Cardoso, Andre Luiz Herzog and de Santiago, Thiago Melo and Rebelo, Luciana Magalhaes and de Moreira, Renato Azevedo and de Oliveira Monteiro-Moreira, Ana Cristina and Campos, Adriana Rolim}, biburl = {https://www.bibsonomy.org/bibtex/29524ceb0b592c438981030a780f84aad/ppgfis_ufc_br}, doi = {10.1007/s10989-014-9398-8}, interhash = {8d340238e78c7045b738c11621c21f46}, intrahash = {9524ceb0b592c438981030a780f84aad}, issn = {1573-3149}, journal = {INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS}, keywords = {Ethanol-induced Frutalin; Gastroprotective; Microscopic analysis} gastric incisa; injury; {Artocarpus}, number = 3, pages = {325-332}, publisher = {SPRINGER}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Ethanol-Induced Gastric Injury: Microscopic Analysis of the Protective Effect of Frutalin}, tppubtype = {article}, volume = 20, year = 2014 }