%0 Journal Article %1 Padda2011 %A Padda, Manmeet S. %A Sanchez, Mayra %A Akhtar, Abbasi J. %A Boyer, James L. %D 2011 %J Hepatology %K safety drugs drug dosage/adverse %N 4 %P 1377--1387 %R 10.1002/hep.24229 %T Drug-induced cholestasis. %U http://dx.doi.org/10.1002/hep.24229 %V 53 %X Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.

@article{Padda2011, abstract = {Recent progress in understanding the molecular mechanisms of bile formation and cholestasis have led to new insights into the pathogenesis of drug-induced cholestasis. This review summarizes their variable clinical presentations, examines the role of transport proteins in hepatic drug clearance and toxicity, and addresses the increasing importance of genetic determinants, as well as practical aspects of diagnosis and management.}, added-at = {2013-08-19T03:01:27.000+0200}, author = {Padda, Manmeet S. and Sanchez, Mayra and Akhtar, Abbasi J. and Boyer, James L.}, biburl = {https://www.bibsonomy.org/bibtex/22952aade061bc51ff804bf0310380905/aorchid}, description = {good review for clinical cases and teaching.}, doi = {10.1002/hep.24229}, file = {:ID_General/Hepatology.53.1377.pdf:PDF}, groups = {public}, institution = {Division of Gastroenterology, Centennial Hills Hospital Medical Center, Las Vegas, NV, USA.}, interhash = {8e35e530edec5973021317557da392ce}, intrahash = {2952aade061bc51ff804bf0310380905}, journal = {Hepatology}, keywords = {safety drugs drug dosage/adverse}, language = {eng}, medline-pst = {ppublish}, month = Apr, number = 4, pages = {1377--1387}, pmid = {21480339}, timestamp = {2013-08-19T03:01:27.000+0200}, title = {Drug-induced cholestasis.}, url = {http://dx.doi.org/10.1002/hep.24229}, username = {aorchid}, volume = 53, year = 2011 }