%0 Journal Article %1 Nelson1979 %A Nelson, K. B. %A Ellenberg, J. H. %D 1979 %J Pediatrics %K Apgar Score; Birth Weight; Cephalometry; Cerebral Palsy; Child; Female; Gestational Age; Humans; Infant, Newborn; Neurologic Examination; Nurseries, Hospital; Pregnancy; Prognosis; Prospective Studies; Risk %N 2 %P 225--232 %T Neonatal signs as predictors of cerebral palsy. %V 64 %X Signs of neonatal neurologic dysfunction, recorded in approximately 40,000 infants, were evaluated prospectively for their ability to predict later motor handicap. Tenfold to 33-fold increases in risk of cerebral palsy (CP) were observed in surviving children with any one of the following characteristics: birth weight less than 2,000 gm, head circumference more than 3 SD above or below the mean, five minute Apgar score of 3 or less, diminished activity or diminished cry lasting for more than one day, thermal instability, need for gavage feeding, hypotonia or hypertonia, single or multiple apneic episodes, or hematocrit less than 40\%. Of worse portent, with relative risks exceeding 50, were neonatal seizures or Apgar scores of 3 or less at ten minutes or later. These characteristics were also markers of considerable risk of early death. For 0.5\% of surviving infants, an overall impression of abnormality of brain function during the nursery period was recorded by the attending physician; there was a 99-fold increase in CP among these children.

@article{Nelson1979, abstract = {Signs of neonatal neurologic dysfunction, recorded in approximately 40,000 infants, were evaluated prospectively for their ability to predict later motor handicap. Tenfold to 33-fold increases in risk of cerebral palsy (CP) were observed in surviving children with any one of the following characteristics: birth weight less than 2,000 gm, head circumference more than 3 SD above or below the mean, five minute Apgar score of 3 or less, diminished activity or diminished cry lasting for more than one day, thermal instability, need for gavage feeding, hypotonia or hypertonia, single or multiple apneic episodes, or hematocrit less than 40\%. Of worse portent, with relative risks exceeding 50, were neonatal seizures or Apgar scores of 3 or less at ten minutes or later. These characteristics were also markers of considerable risk of early death. For 0.5\% of surviving infants, an overall impression of abnormality of brain function during the nursery period was recorded by the attending physician; there was a 99-fold increase in CP among these children.}, added-at = {2014-07-19T20:54:03.000+0200}, author = {Nelson, K. B. and Ellenberg, J. H.}, biburl = {https://www.bibsonomy.org/bibtex/2e689a631e418f56c77c2bd05c11ea074/ar0berts}, groups = {public}, interhash = {941e73301329c19d2e08d8df463eda51}, intrahash = {e689a631e418f56c77c2bd05c11ea074}, journal = {Pediatrics}, keywords = {Apgar Score; Birth Weight; Cephalometry; Cerebral Palsy; Child; Female; Gestational Age; Humans; Infant, Newborn; Neurologic Examination; Nurseries, Hospital; Pregnancy; Prognosis; Prospective Studies; Risk}, month = Aug, number = 2, pages = {225--232}, pmid = {471612}, timestamp = {2014-07-19T20:54:03.000+0200}, title = {Neonatal signs as predictors of cerebral palsy.}, username = {ar0berts}, volume = 64, year = 1979 }