%0 Conference Paper %1 10399204 %A Pennazio, Francesco %A Werner, Julius %A Aglietta, Marco %A Cerello, Piergiorgio %A Fiorina, Elisa %A Garbolino, Sara %A Monaco, Vincenzo %A Vignati, Anna %A Wheadon, Richard %A Ferrero, Veronica %A Rafecas, Magdalena %B 2022 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) %D 2022 %K %R 10.1109/NSS/MIC44845.2022.10399204 %T Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain %X Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.

@inproceedings{10399204, abstract = {Prompt Gamma Timing is a technique proposed for range monitoring in proton therapy. The experimental measurements so far are limited to a single secondary proton detector. In this study we present an innovative technique to merge the information from many detectors in different positions into a unique estimation of the beam particle motion in the spatiotemporal domain. We test the proposed method by means of Monte Carlo simulations, with various beam ranges and a number of primaries interesting for proton therapy monitoring (107). The method is based on the Maximum Likelihood Expectation Maximization algorithm, and we show its applicability with both MeV-range gamma detectors as well as lower energy detectors such as PET detectors. The preliminary results shown indicate a range resolution of about 5 mm. The ultimate goal of this study is to provide a robust mathematical instrument to expand the significance of Prompt Gamma Timing measurements, to be useful for the prototypes presently under construction by the treatment monitoring community.}, added-at = {2024-01-29T09:48:18.000+0100}, author = {Pennazio, Francesco and Werner, Julius and Aglietta, Marco and Cerello, Piergiorgio and Fiorina, Elisa and Garbolino, Sara and Monaco, Vincenzo and Vignati, Anna and Wheadon, Richard and Ferrero, Veronica and Rafecas, Magdalena}, biburl = {https://www.bibsonomy.org/bibtex/2460ec95c0ea7419f32f7972f8eeed749/imt_bibsonomy}, booktitle = {2022 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC)}, doi = {10.1109/NSS/MIC44845.2022.10399204}, interhash = {94a076ffd5eab7be8263843ab4f3e65a}, intrahash = {460ec95c0ea7419f32f7972f8eeed749}, issn = {2577-0829}, keywords = {}, month = nov, timestamp = {2024-01-29T09:48:18.000+0100}, title = {Proton Therapy Treatment Monitoring: Prompt Gamma Emission Reconstruction in the Time and Space Domain}, year = 2022 }