Article,
In vitro evaluation of anti-calcification and anti-coagulation on sulfonated chitosan and carrageenan surfaces
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, (2016)
DOI: 10.1016/j.msec.2015.10.020
Abstract
In recent years, great effort has been devoted to the development of
biomaterials that come into contact with blood. The surfaces of these
materials need to be of suitable mechanical strength, and present
anti-thrombogenic and anti-calcification properties. Chitosan is a
natural polymer that has attracted attention due to its potential to act
as a biomaterial. However, chitosan contains amino groups in its
structure that may promote thrombogenesis and calcification. A strategy
to reduce these properties constitutes the introduction of sulfonate
groups (R-SO3-) in the chitosan chain. Another interesting biopolymer
with similar characteristics to those of heparin is carrageenan, which
has sulfate groups in its structure. As such, we evaluated ``in
vitro'' calcification and thrombogenic processes on surfaces of
pristine and sulfonated chitosan and on polyelectrolyte complexes (PEC)
of chitosan and carrageenan. Results indicate that PEC demonstrate
significant reductions in calcification and thrombogenic potential,
probably due to the presence of sulfonate groups in both the carrageenan
and treated chitosan. (C) 2015 Elsevier B.V. All rights reserved.
