%0 Journal Article %1 DeAngelis:2012er %A DeAngelis, Robert A. %A Markiewski, Maciej M. %A Kourtzelis, Ioannis %A Rafail, Stavros %A Syriga, Maria %A Sandor, Adam %A Maurya, Mano R. %A Gupta, Shakti %A Subramaniam, Shankar %A Lambris, John D. %D 2012 %J Journal of Immunology %K imported %N 2 %P 641--648 %R 10.4049/jimmunol.1101925 %T A Complement-IL-4 Regulatory Circuit Controls Liver Regeneration %U http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22184721&retmode=ref&cmd=prlinks %V 188 %X The involvement of IL-4 in liver regeneration has not yet been recognized. In this article, we show that IL-4, produced by NKT cells that accumulate in regenerating livers after partial hepatectomy, contributes to this process by regulating the activation of complement after liver resection in mice. The mechanism of this regulation was associated with the maintenance of an appropriate level of IgM in mouse blood, because IgM deposited in liver parenchyma most likely initiated complement activation during liver regeneration. By controlling complement activation, IL-4 regulated the induction of IL-6, thereby influencing a key pathway involved in regenerating liver cell proliferation and survival. Furthermore, the secretion of IL-4 was controlled by complement through the recruitment of NKT cells to regenerating livers. Our study thus reveals the existence of a regulatory feedback mechanism involving complement and IL-4 that controls liver regeneration. The Journal of Immunology, 2012, 188: 641-648.

@article{DeAngelis:2012er, abstract = {The involvement of IL-4 in liver regeneration has not yet been recognized. In this article, we show that IL-4, produced by NKT cells that accumulate in regenerating livers after partial hepatectomy, contributes to this process by regulating the activation of complement after liver resection in mice. The mechanism of this regulation was associated with the maintenance of an appropriate level of IgM in mouse blood, because IgM deposited in liver parenchyma most likely initiated complement activation during liver regeneration. By controlling complement activation, IL-4 regulated the induction of IL-6, thereby influencing a key pathway involved in regenerating liver cell proliferation and survival. Furthermore, the secretion of IL-4 was controlled by complement through the recruitment of NKT cells to regenerating livers. Our study thus reveals the existence of a regulatory feedback mechanism involving complement and IL-4 that controls liver regeneration. The Journal of Immunology, 2012, 188: 641-648.}, added-at = {2017-12-08T05:18:19.000+0100}, affiliation = {Univ Penn, Dept Pathol {\&} Lab Med, Philadelphia, PA 19104 USA}, author = {DeAngelis, Robert A. and Markiewski, Maciej M. and Kourtzelis, Ioannis and Rafail, Stavros and Syriga, Maria and Sandor, Adam and Maurya, Mano R. and Gupta, Shakti and Subramaniam, Shankar and Lambris, John D.}, biburl = {https://www.bibsonomy.org/bibtex/2a2d4fce2374336c35d3a026e14d9058c/lambris}, date-added = {2012-03-27T20:48:57GMT}, date-modified = {2017-12-08T04:17:03GMT}, doi = {10.4049/jimmunol.1101925}, interhash = {972ad7ffe0b126adb749cc76dafb0233}, intrahash = {a2d4fce2374336c35d3a026e14d9058c}, journal = {Journal of Immunology}, keywords = {imported}, language = {English}, number = 2, pages = {641--648}, pmcid = {PMC3253144}, pmid = {22184721}, rating = {0}, timestamp = {2017-12-08T05:18:19.000+0100}, title = {{A Complement-IL-4 Regulatory Circuit Controls Liver Regeneration}}, uri = {\url{papers3://publication/doi/10.4049/jimmunol.1101925}}, url = {http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=22184721&retmode=ref&cmd=prlinks}, volume = 188, year = 2012 }