%0 Journal Article %1 Sommer2007 %A Sommer, C. %A Urlesberger, B. %A Maurer-Fellbaum, U. %A Kutschera, J. %A M?ller, W. %D 2007 %J Klin Padiatr %K Body Weight; Brain Damage, Chronic; Cephalometry; Cerebral Palsy; Child, Preschool; Comorbidity; Developmental Disabilities; Disabled Children; Female; Follow-Up Studies; Humans; Infant; Infant, Extremely Low Birth Newborn; Premature, Diseases; Male; Neurologic Examination; Pregnancy; Pregnancy Trimester, Second; Survival Rate %N 1 %P 23--29 %R 10.1055/s-2006-921341 %T Neurodevelopmental outcome at 2 years in 23 to 26 weeks old gestation infants. %U http://dx.doi.org/10.1055/s-2006-921341 %V 219 %X BACKGROUND: Assessment of neurologic and developmental outcome at 2 years age of infants with gestational age (GA)<27 weeks, born between 1996-2001. PATIENTS: A total of 110 live-born preterm infants with GA<27 weeks. METHODS: Main outcome criterions: Neurologic examination (according to Touwen) and classification of cerebral palsy by using the Gross Motor Function Classification System (GMFCS) at the corrected age of 1 and 2 years; assessment of mental and psychomotor development by using the Griffith Mental Development scales at the corrected age of 2 years; growth assessment at birth, 1 and 2 years. RESULTS: Mortality was 52\%. Regular follow up was performed in 48 (91\%) of the 53 surviving infants. Neurologic outcome: at 1 year age: 2\% nonambulant cerebral palsy, 25\% mild neurologic signs and 73\% normal; at 2 years age: 4\% nonambulant cerebral palsy, 2\% ambulant cerebral palsy, 4\% mild neurologic signs and 90\% normal neurology. Developmental outcome at 2 years age: 40\% DQ>-1 SD, 6\% DQ between -1 SD and -2 SD (mild delay), 35\% DQ between -2 SD and -3 SD (moderate delay) and 19\% DQ<-3 SD (severe delay). Overall disability was found in 64\%, severe disability in 27\% of the infants. Profound growth failure in weight and head circumference<3rd centile at 2 years age was recorded in 39 and 19\% of the infants, respectively. CONCLUSION: Developmental delay is very common in preterm infants<27 GA and exceeds the number of neurological disabilities (including cerebral palsy).

@article{Sommer2007, abstract = {BACKGROUND: Assessment of neurologic and developmental outcome at 2 years age of infants with gestational age (GA)<27 weeks, born between 1996-2001. PATIENTS: A total of 110 live-born preterm infants with GA<27 weeks. METHODS: Main outcome criterions: Neurologic examination (according to Touwen) and classification of cerebral palsy by using the Gross Motor Function Classification System (GMFCS) at the corrected age of 1 and 2 years; assessment of mental and psychomotor development by using the Griffith Mental Development scales at the corrected age of 2 years; growth assessment at birth, 1 and 2 years. RESULTS: Mortality was 52\%. Regular follow up was performed in 48 (91\%) of the 53 surviving infants. Neurologic outcome: at 1 year age: 2\% nonambulant cerebral palsy, 25\% mild neurologic signs and 73\% normal; at 2 years age: 4\% nonambulant cerebral palsy, 2\% ambulant cerebral palsy, 4\% mild neurologic signs and 90\% normal neurology. Developmental outcome at 2 years age: 40\% DQ>-1 SD, 6\% DQ between -1 SD and -2 SD (mild delay), 35\% DQ between -2 SD and -3 SD (moderate delay) and 19\% DQ<-3 SD (severe delay). Overall disability was found in 64\%, severe disability in 27\% of the infants. Profound growth failure in weight and head circumference<3rd centile at 2 years age was recorded in 39 and 19\% of the infants, respectively. CONCLUSION: Developmental delay is very common in preterm infants<27 GA and exceeds the number of neurological disabilities (including cerebral palsy).}, added-at = {2014-07-19T21:22:38.000+0200}, author = {Sommer, C. and Urlesberger, B. and Maurer-Fellbaum, U. and Kutschera, J. and M?ller, W.}, biburl = {https://www.bibsonomy.org/bibtex/2a3538f4ac81b1563c74d2ec6d6e103a5/ar0berts}, doi = {10.1055/s-2006-921341}, groups = {public}, interhash = {9c2607d8f9a1faa819cef96830dfb2c3}, intrahash = {a3538f4ac81b1563c74d2ec6d6e103a5}, journal = {Klin Padiatr}, keywords = {Body Weight; Brain Damage, Chronic; Cephalometry; Cerebral Palsy; Child, Preschool; Comorbidity; Developmental Disabilities; Disabled Children; Female; Follow-Up Studies; Humans; Infant; Infant, Extremely Low Birth Newborn; Premature, Diseases; Male; Neurologic Examination; Pregnancy; Pregnancy Trimester, Second; Survival Rate}, number = 1, pages = {23--29}, pmid = {16586271}, timestamp = {2014-07-19T21:22:38.000+0200}, title = {Neurodevelopmental outcome at 2 years in 23 to 26 weeks old gestation infants.}, url = {http://dx.doi.org/10.1055/s-2006-921341}, username = {ar0berts}, volume = 219, year = 2007 }