Abstract
BACKGROUND: An association has been described between mortality in children with meningococcal disease and functional polymorphisms in the interleukin-1 (IL1) cluster. We undertook a multicenter study to evaluate associations of these polymorphisms in a Central European population. PATIENTS AND METHODS: The study involved 95 Middle European pediatric hospitals. We collected blood samples from, and clinical information about, 285 previously healthy children with meningococcal infection. We used a newly developed multiplexed mutagenic separated PCR assay to analyze 6 polymorphisms within the IL1 cluster: IL1A (-889)C/T, IL1A (+4845)G/T, IL1B (-511)C/T, IL1B (-31)C/T, IL1B (+3954), and IL1RA (+2018)C/T. We studied the same polymorphisms in a comparison group of 481 healthy newborns. RESULTS: Genotype frequencies between patients and the comparison group differed significantly only for the IL1RA (+2018)C/T variant: The CC genotype was more frequent in patients (11\%) than in healthy controls (5\%; P = 0.008). In the patient group, the C allele was significantly more prevalent (67\%) in nonsurvivors than in survivors (42\%; P = 0.02). CONCLUSION: The IL1RA (+2018)C/T polymorphism is associated with the risk of meningococcal disease and with its outcome.
- adolescent,
- adult,
- ancestry
- child,
- continental
- disease,
- europe,
- european
- family,
- female,
- frequency,
- gene
- genetic
- genotype,
- group,
- humans,
- infant,
- infections,
- interleukin-1,
- male,
- meningococcal
- multigene
- newborn,
- polymorphism,
- predisposition
- preschool,
- to
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