%0 Journal Article %1 park2016directed %A Park, JinSeok %A Kim, Deok-Ho %A Kim, Hong-Nam %A Wang, Chiaochun Joanne %A Kwak, Moon Kyu %A Hur, Eunmi %A Suh, Kahp-Yang %A An, Steven S. %A Levchenko, Andre %D 2016 %I Nature Publishing Group %J Nat Mater %K migration nextgen topography %T Directed migration of cancer cells guided by the graded texture of the underlying matrix %U http://dx.doi.org/10.1038/nmat4586 %V advance online publication %X Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define key developmental, physiological and pathological processes. Here, we report a new type of directed migrationmdashwhich we term /`topotaxis/'mdashguided by the gradient of the nanoscale topographic features in the cells/' ECM environment. We show that the direction of topotaxis is reflective of the effective cell stiffness, and that it depends on the balance of the ECM-triggered signalling pathways PI(3)K-Akt and ROCK-MLCK. In melanoma cancer cells, this balance can be altered by different ECM inputs, pharmacological perturbations or genetic alterations, particularly a loss of PTEN in aggressive melanoma cells. We conclude that topotaxis is a product of the material properties of cells and the surrounding ECM, and propose that the invasive capacity of many cancers may depend broadly on topotactic responses, providing a potentially attractive mechanism for controlling invasive and metastatic behaviour.

@article{park2016directed, abstract = {Living cells and the extracellular matrix (ECM) can exhibit complex interactions that define key developmental, physiological and pathological processes. Here, we report a new type of directed migration[mdash]which we term /`topotaxis/'[mdash]guided by the gradient of the nanoscale topographic features in the cells/' ECM environment. We show that the direction of topotaxis is reflective of the effective cell stiffness, and that it depends on the balance of the ECM-triggered signalling pathways PI(3)K-Akt and ROCK-MLCK. In melanoma cancer cells, this balance can be altered by different ECM inputs, pharmacological perturbations or genetic alterations, particularly a loss of PTEN in aggressive melanoma cells. We conclude that topotaxis is a product of the material properties of cells and the surrounding ECM, and propose that the invasive capacity of many cancers may depend broadly on topotactic responses, providing a potentially attractive mechanism for controlling invasive and metastatic behaviour.}, added-at = {2016-07-21T14:33:54.000+0200}, author = {Park, JinSeok and Kim, Deok-Ho and Kim, Hong-Nam and Wang, Chiaochun Joanne and Kwak, Moon Kyu and Hur, Eunmi and Suh, Kahp-Yang and An, Steven S. and Levchenko, Andre}, biburl = {https://www.bibsonomy.org/bibtex/2e45c7aa981663fdb68c54c19c832c464/bkoch}, description = {Directed migration of cancer cells guided by the graded texture of the underlying matrix : Nature Materials : Nature Research}, interhash = {ab58a3fc02f1292d23337ce453408ef9}, intrahash = {e45c7aa981663fdb68c54c19c832c464}, issn = {14764660}, journal = {Nat Mater}, keywords = {migration nextgen topography}, month = mar, publisher = {Nature Publishing Group}, timestamp = {2016-07-21T14:33:54.000+0200}, title = {Directed migration of cancer cells guided by the graded texture of the underlying matrix}, url = {http://dx.doi.org/10.1038/nmat4586}, volume = {advance online publication}, year = 2016 }