Abstract
Allergic diseases have reached epidemic proportions worldwide. An
understanding of the cellular and soluble mediators that are involved in
allergic inflammatory responses not only helps in understanding the
mechanisms of current treatments, but is also important for the
identification of new targets that are amenable to both small-molecule
and biological interventions. There is now considerable optimism with
regards to tackling the allergy epidemic in light of improvements in
systemic and mucosal allergen-specific immunotherapy, the identification
of key cytokines and their receptors that drive T-helper-2-cell
polarization, a clearer understanding of the pathways of leukocyte
recruitment and the signalling pathways that are involved in cell
activation and mediator secretion, and new approaches to vaccine
development.
Users
Please
log in to take part in the discussion (add own reviews or comments).