Abstract
Conjugate vaccines against Haemophilus influenzae type b (Hib) may modify Hib pharyngeal colonization. Hib colonization was compared in 371 infants and their families. In Oxfordshire, infants received PRP-T (polyribosylribitol phosphate conjugated to tetanus toxoid) and in Buckinghamshire they did not (controls). Infants were followed at 6, 9, and 12 months of age. Also, 6 unvaccinated Hib carriers were vaccinated and followed for 6 weeks. Hib acquisition was lower in vaccinees than controls (P \textless .01). During surveillance, 1.5\% of vaccinees and 6.3\% of controls carried Hib (P = .04). Among those with family Hib exposure, the carriage rates were 8.7\% and 38.5\% (P = .07), respectively. Hiv carriage rates were lower among vaccinees' unvaccinated siblings. Giving conjugate vaccine to a child carrying Hib did not rapidly terminate carriage. Thus, a primary means by which herd immunity to Hib is induced in a vaccinated population may be through reduction or delay in the initial acquisition of Hib.
- bacterial
- capsules,
- carrier
- cohort
- conjugate
- family
- family,
- female,
- haemophilus
- health,
- humans,
- infant,
- infections,
- influenzae,
- male,
- mothers,
- nuclear
- pharynx,
- questionnaires,
- state,
- studies,
- tetanus
- toxoid,
- vaccination,
- vaccines,
- {case-control}
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