%0 Journal Article %1 Verderio.2010 %A Verderio, Paolo %A Pizzamiglio, Sara %A Southey, Melissa C. %A Spurdle, Amanda B. %A Hopper, John L. %A Chen, Xiaoqing %A Beesley, Jonathan %A Schmutzler, Rita K. %A Engel, Christoph %A Burwinkel, Barbara %A Bugert, Peter %A Ficarazzi, Filomena %A Manoukian, Siranoush %A Barile, Monica %A Wappenschmidt, Barbara %A Chenevix-Trench, Georgia %A Radice, Paolo %A Peterlongo, Paolo %D 2010 %J Journal of medical genetics %K BRCA1_Protein/genetics Breast_Neoplasms/genetics Case-Control_Studies Female Genes,_BRCA1 Genetic_Predisposition_to_Disease Genome-Wide_Association_Study Humans Logistic_Models Polymorphism,_Single_Nucleotide Promoter_Regions,_Genetic %N 4 %P 268–270 %T A BRCA1 promoter variant (rs11655505) and breast cancer risk %V 47 %X BACKGROUND\r\nA study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.\r\nMETHODS\r\nWe genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.\r\nRESULTS\r\nNo evidence for an association between rs11655505 and breast cancer risk was found.\r\nCONCLUSIONS\r\nOur study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.

@article{Verderio.2010, abstract = {BACKGROUND\r\nA study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.\r\nMETHODS\r\nWe genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.\r\nRESULTS\r\nNo evidence for an association between rs11655505 and breast cancer risk was found.\r\nCONCLUSIONS\r\nOur study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.}, added-at = {2014-10-14T15:28:14.000+0200}, author = {Verderio, Paolo and Pizzamiglio, Sara and Southey, Melissa C. and Spurdle, Amanda B. and Hopper, John L. and Chen, Xiaoqing and Beesley, Jonathan and Schmutzler, Rita K. and Engel, Christoph and Burwinkel, Barbara and Bugert, Peter and Ficarazzi, Filomena and Manoukian, Siranoush and Barile, Monica and Wappenschmidt, Barbara and Chenevix-Trench, Georgia and Radice, Paolo and Peterlongo, Paolo}, biburl = {https://www.bibsonomy.org/bibtex/286fc0ace8073dc63d97f495e739bc649/drtester}, interhash = {b4a7fac38a0872c79d27dd41bb77ae0b}, intrahash = {86fc0ace8073dc63d97f495e739bc649}, journal = {Journal of medical genetics}, keywords = {BRCA1_Protein/genetics Breast_Neoplasms/genetics Case-Control_Studies Female Genes,_BRCA1 Genetic_Predisposition_to_Disease Genome-Wide_Association_Study Humans Logistic_Models Polymorphism,_Single_Nucleotide Promoter_Regions,_Genetic}, number = 4, pages = {268–270}, timestamp = {2014-10-14T15:28:14.000+0200}, title = {A BRCA1 promoter variant (rs11655505) and breast cancer risk}, volume = 47, year = 2010 }