%0 Journal Article %1 Kaltenbach2009Systems %A Kaltenbach, Hans-Michael %A Dimopoulos, Sotiris %A Stelling, Jörg %D 2009 %J FEBS Letters %K modelling uncertainty %N 24 %P 3923 - 3930 %R https://doi.org/10.1016/j.febslet.2009.10.074 %T Systems analysis of cellular networks under uncertainty %U http://www.sciencedirect.com/science/article/pii/S0014579309008667 %V 583 %X Besides the often-quoted complexity of cellular networks, the prevalence of uncertainties about components, interactions, and their quantitative features provides a largely underestimated hallmark of current systems biology. This uncertainty impedes the development of mechanistic mathematical models to achieve a true systems-level understanding. However, there is increasing evidence that theoretical approaches from diverse scientific domains can extract relevant biological knowledge efficiently, even from poorly characterized biological systems. As a common denominator, the methods focus on structural, rather than more detailed, kinetic network properties. A deeper understanding, better scaling, and the ability to combine the approaches pose formidable challenges for future theory developments.

@article{Kaltenbach2009Systems, abstract = {Besides the often-quoted complexity of cellular networks, the prevalence of uncertainties about components, interactions, and their quantitative features provides a largely underestimated hallmark of current systems biology. This uncertainty impedes the development of mechanistic mathematical models to achieve a true systems-level understanding. However, there is increasing evidence that theoretical approaches from diverse scientific domains can extract relevant biological knowledge efficiently, even from poorly characterized biological systems. As a common denominator, the methods focus on structural, rather than more detailed, kinetic network properties. A deeper understanding, better scaling, and the ability to combine the approaches pose formidable challenges for future theory developments.}, added-at = {2019-06-12T08:59:42.000+0200}, author = {Kaltenbach, Hans-Michael and Dimopoulos, Sotiris and Stelling, Jörg}, biburl = {https://www.bibsonomy.org/bibtex/21bddf9c6f28e0e18e8bd43e736e8ed5e/karthikraman}, description = {Systems analysis of cellular networks under uncertainty - ScienceDirect}, doi = {https://doi.org/10.1016/j.febslet.2009.10.074}, interhash = {b5d3ac1cb22709c0a11c252a0d27aaa5}, intrahash = {1bddf9c6f28e0e18e8bd43e736e8ed5e}, issn = {0014-5793}, journal = {FEBS Letters}, keywords = {modelling uncertainty}, note = {Systems Biology - Nobel Symposium 146}, number = 24, pages = {3923 - 3930}, timestamp = {2019-06-12T08:59:42.000+0200}, title = {Systems analysis of cellular networks under uncertainty}, url = {http://www.sciencedirect.com/science/article/pii/S0014579309008667}, volume = 583, year = 2009 }