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Time-resolved optical tomography using short-pulse laser for tumor detection
(2006)
Аннотация
Our objective is to perform a comprehensive experimental and numerical
analysis of the short-pulse laser interaction with a tissue medium
with the goal of tumor-cancer diagnostics. For a short-pulse laser
source, the shape of the output signal is a function of the optical
properties of the medium, and hence the scattered temporal optical
signal helps in understanding the medium characteristics. Initially
experiments are performed on tissue phantoms embedded with inhomogeneities
to optimize the time-resolved optical detection scheme. Both the
temporal and the spatial profiles of the scattered reflected and
transmitted optical signals are compared with the numerical modeling
results obtained by solving the transient radiative transport equation
using the discrete. ordinates technique. Next experiments are performed
on in vitro rat tissue samples to characterize the interaction of
light with skin layers and to validate the time-varying optical signatures
with the numerical model. The numerical modeling results and the
experimental measurements are in excellent agreement for the different
parameters studied. The final step is to perform in vivo imaging
of anesthetized rats with tumor-promoting agents injected inside
skin tissues and of an anesthetized mouse with mammary tumors to
demonstrate the feasibility of the technique for detecting tumors
in an animal model. (C) 2006 Optical Society of America.
