%0 Journal Article %1 Ciani2017 %A Ciani, Oriana %A Buyse, Marc %A Drummond, Michael %A Rasi, Guido %A Saad, Everardo D %A Taylor, Rod S %D 2017 %J Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research %K clinicaloutcomeassessment healthtechnologyassessment surrogateendpoints validation %N 3 %P 487-495 %R 10.1016/j.jval.2016.10.011 %T Time to Review the Role of Surrogate End Points in Health Policy: State of the Art and the Way Forward. %U http://linkinghub.elsevier.com/retrieve/pii/S1098301516340657 http://www.ncbi.nlm.nih.gov/pubmed/28292495 %V 20 %X The efficacy of medicines, medical devices, and other health technologies should be proved in trials that assess final patient-relevant outcomes such as survival or morbidity. Market access and coverage decisions are, however, often based on surrogate end points, biomarkers, or intermediate end points, which aim to substitute and predict patient-relevant outcomes that are unavailable because of methodological, financial, or practical constraints. We provide a summary of the present use of surrogate end points in health care policy, discussing the case for and against their adoption and reviewing validation methods. We introduce a three-step framework for policymakers to handle surrogates, which involves establishing the level of evidence, assessing the strength of the association, and quantifying relations between surrogates and final outcomes. Although the use of surrogates can be problematic, they can, when selected and validated appropriately, offer important opportunities for more efficient clinical trials and faster access to new health technologies that benefit patients and health care systems.

@article{Ciani2017, abstract = {The efficacy of medicines, medical devices, and other health technologies should be proved in trials that assess final patient-relevant outcomes such as survival or morbidity. Market access and coverage decisions are, however, often based on surrogate end points, biomarkers, or intermediate end points, which aim to substitute and predict patient-relevant outcomes that are unavailable because of methodological, financial, or practical constraints. We provide a summary of the present use of surrogate end points in health care policy, discussing the case for and against their adoption and reviewing validation methods. We introduce a three-step framework for policymakers to handle surrogates, which involves establishing the level of evidence, assessing the strength of the association, and quantifying relations between surrogates and final outcomes. Although the use of surrogates can be problematic, they can, when selected and validated appropriately, offer important opportunities for more efficient clinical trials and faster access to new health technologies that benefit patients and health care systems.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Ciani, Oriana and Buyse, Marc and Drummond, Michael and Rasi, Guido and Saad, Everardo D and Taylor, Rod S}, biburl = {https://www.bibsonomy.org/bibtex/29dd8cde1093d9d0ddc7db5ae96783d8e/jepcastel}, doi = {10.1016/j.jval.2016.10.011}, interhash = {bc6b7a633c3b011553b96ee525faf6f7}, intrahash = {9dd8cde1093d9d0ddc7db5ae96783d8e}, issn = {1524-4733}, journal = {Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research}, keywords = {clinicaloutcomeassessment healthtechnologyassessment surrogateendpoints validation}, month = {3}, note = {Mesures de resultats; Surrogate endpoints}, number = 3, pages = {487-495}, pmid = {28292495}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Time to Review the Role of Surrogate End Points in Health Policy: State of the Art and the Way Forward.}, url = {http://linkinghub.elsevier.com/retrieve/pii/S1098301516340657 http://www.ncbi.nlm.nih.gov/pubmed/28292495}, volume = 20, year = 2017 }