%0 Journal Article %1 Lane1999 %A Lane, D A %A Kramer, M S %D 1999 %J Journal of clinical epidemiology %K Adolescent Adult Aged AppetiteDepressants AppetiteDepressants:adverseeffects Belgium Belgium:epidemiology Child Dexfenfluramine Dexfenfluramine:adverseeffects DrugPrescriptions DrugPrescriptions:economics DrugPrescriptions:statistics&numericaldata DrugUtilization DrugUtilization:economics DrugUtilization:statistics&numericaldata DrugandNarcoticControl DrugandNarcoticControl:economics DrugandNarcoticControl:legislation&jurisprud DrugandNarcoticControl:statistics&numerical Female France France:epidemiology Humans Hypertension Incidence Male MiddleAged Models Pharmacoepidemiology Pharmacoepidemiology:methods Pulmonary Pulmonary:chemicallyinduced Pulmonary:economics Pulmonary:epidemiology RetrospectiveStudies SerotoninReceptorAgonists SerotoninReceptorAgonists:adverseeffects Statistical %N 12 %P 1279-87 %T Determining exposure underreporting in pharmacoepidemiologic case-control studies: methods and example. %U http://www.ncbi.nlm.nih.gov/pubmed/10580792 %V 52 %X Many pharmacoepidemiologic case-control studies have to rely on what their subjects relate about the drugs to which they have been exposed and the durations of exposure. There is often good reason to suppose that not all exposures are actually reported and to suspect reporting rates may differ between cases and controls. We introduce two procedures designed to determine the extent of underreporting of exposures. These procedures make use of data from the case-control study itself, as well as sales, demographic and market research data for a reference population to which study subjects belong. We apply these procedures to data from the International Primary Pulmonary Hypertension Study (IPPHS) linking anorexigens with PPH. We show that exposures to the anorectic agent dexfenfluramine beginning in or before 1989 were highly significantly underrepresented in the data for IPPHS controls, relative to exposures beginning after 1989 (P<0.01); there is no corresponding evidence for relative underrepresentation of early exposure for IPPHS cases. However, data on control exposures from 1990 to 1992 are consistent with the hypothesis that these exposures were not underreported to the IPPHS. Subject to certain key modeling assumptions and the availability of some supplemental data, it is possible to investigate the extent of underreporting of exposure in a pharmacoepidemiologic case-control study and in particular to determine if study results are likely to have been affected by recall bias.

@article{Lane1999, abstract = {Many pharmacoepidemiologic case-control studies have to rely on what their subjects relate about the drugs to which they have been exposed and the durations of exposure. There is often good reason to suppose that not all exposures are actually reported and to suspect reporting rates may differ between cases and controls. We introduce two procedures designed to determine the extent of underreporting of exposures. These procedures make use of data from the case-control study itself, as well as sales, demographic and market research data for a reference population to which study subjects belong. We apply these procedures to data from the International Primary Pulmonary Hypertension Study (IPPHS) linking anorexigens with PPH. We show that exposures to the anorectic agent dexfenfluramine beginning in or before 1989 were highly significantly underrepresented in the data for IPPHS controls, relative to exposures beginning after 1989 (P<0.01); there is no corresponding evidence for relative underrepresentation of early exposure for IPPHS cases. However, data on control exposures from 1990 to 1992 are consistent with the hypothesis that these exposures were not underreported to the IPPHS. Subject to certain key modeling assumptions and the availability of some supplemental data, it is possible to investigate the extent of underreporting of exposure in a pharmacoepidemiologic case-control study and in particular to determine if study results are likely to have been affected by recall bias.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Lane, D A and Kramer, M S}, biburl = {https://www.bibsonomy.org/bibtex/208df9d24c09b8f1378505794647273e6/jepcastel}, interhash = {c2e2f013b1b17d0499566e4b56ed3c50}, intrahash = {08df9d24c09b8f1378505794647273e6}, issn = {0895-4356}, journal = {Journal of clinical epidemiology}, keywords = {Adolescent Adult Aged AppetiteDepressants AppetiteDepressants:adverseeffects Belgium Belgium:epidemiology Child Dexfenfluramine Dexfenfluramine:adverseeffects DrugPrescriptions DrugPrescriptions:economics DrugPrescriptions:statistics&numericaldata DrugUtilization DrugUtilization:economics DrugUtilization:statistics&numericaldata DrugandNarcoticControl DrugandNarcoticControl:economics DrugandNarcoticControl:legislation&jurisprud DrugandNarcoticControl:statistics&numerical Female France France:epidemiology Humans Hypertension Incidence Male MiddleAged Models Pharmacoepidemiology Pharmacoepidemiology:methods Pulmonary Pulmonary:chemicallyinduced Pulmonary:economics Pulmonary:epidemiology RetrospectiveStudies SerotoninReceptorAgonists SerotoninReceptorAgonists:adverseeffects Statistical}, month = {12}, note = {2742<m:linebreak></m:linebreak>Mesures d&#039;associació}, number = 12, pages = {1279-87}, pmid = {10580792}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Determining exposure underreporting in pharmacoepidemiologic case-control studies: methods and example.}, url = {http://www.ncbi.nlm.nih.gov/pubmed/10580792}, volume = 52, year = 1999 }