Abstract
While genome sequencing projects are advancing rapidly, EST sequencing
and analysis remains a primary research tool for the identification
and categorization of gene sequences in a wide variety of species
and an important resource for annotation of genomic sequence. The
TIGR Gene Indices (http://www.tigr.org/tdb/tgi.shtml) are a collection
of species-specific databases that use a highly refined protocol
to analyze EST sequences in an attempt to identify the genes represented
by that data and to provide additional information regarding those
genes. Gene Indices are constructed by first clustering, then assembling
EST and annotated gene sequences from GenBank for the targeted species.
This process produces a set of unique, high-fidelity virtual transcripts,
or Tentative Consensus (TC) sequences. The TC sequences can be used
to provide putative genes with functional annotation, to link the
transcripts to mapping and genomic sequence data, to provide links
between orthologous and paralogous genes and as a resource for comparative
sequence analysis.
Users
Please
log in to take part in the discussion (add own reviews or comments).