Abstract
In spontaneously hypertensive rats (SHR), both the response to adenosine
and the affinity of adenosine A1 receptors (A1R) are altered. We
compared the coding sequences and the mRNA expression levels of A1R
in SHR and normotensive Wistar rats (NWTR). Neither the nucleotide
sequence nor the mRNA level of A1R are altered in SHR, so that gene
mutations or an altered gene regulation of A1R cannot account for
alterations in A1R function in SHR.
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