%0 Journal Article %1 Schmitt.2012 %A Schmitt, J. %A Backes, C. %A Nourkami-Tutdibi, N. %A Leidinger, P. %A Deutscher, S. %A Beier, M. %A Gessler, M. %A Graf, N. %A Lenhof, H. P. %A Keller, A. %A Meese, E. %D 2012 %J BMC Genomics %K imported %N 1 %P 379 %T Treatment-independent miRNA signature in blood of wilms tumor patients %V 13 %X ABSTRACT: BACKGROUND: Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared themiRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOPprotocol 2001. RESULTS: We did not find a significant difference between miRNA signature of both groups. However both, Wilmstumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. Thesignature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5\% and of patients afterchemotherapy an accuracy of 97.0\%, each as compared to healthy controls. CONCLUSION: Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of fourweeks preoperative chemotherapy treatment.

@article{Schmitt.2012, abstract = {ABSTRACT: BACKGROUND: Blood-born miRNA signatures have recently been reported for various tumor diseases. Here, we compared themiRNA signature in Wilms tumor patients prior and after preoperative chemotherapy according to SIOPprotocol 2001. RESULTS: We did not find a significant difference between miRNA signature of both groups. However both, Wilmstumor patients prior and after chemotherapy showed a miRNA signature different from healthy controls. Thesignature of Wilms tumor patients prior to chemotherapy showed an accuracy of 97.5{\%} and of patients afterchemotherapy an accuracy of 97.0{\%}, each as compared to healthy controls. CONCLUSION: Our results provide evidence for a blood-born Wilms tumor miRNA signature largely independent of fourweeks preoperative chemotherapy treatment.}, added-at = {2013-01-29T13:47:26.000+0100}, author = {Schmitt, J. and Backes, C. and Nourkami-Tutdibi, N. and Leidinger, P. and Deutscher, S. and Beier, M. and Gessler, M. and Graf, N. and Lenhof, H. P. and Keller, A. and Meese, E.}, biburl = {https://www.bibsonomy.org/bibtex/2120d40cd2d7ff69fa104602129d6d146/ebch}, interhash = {d67535778998e21bd1c6201029d7637f}, intrahash = {120d40cd2d7ff69fa104602129d6d146}, journal = {BMC Genomics}, keywords = {imported}, number = 1, pages = 379, timestamp = {2013-01-29T13:47:26.000+0100}, title = {Treatment-independent miRNA signature in blood of wilms tumor patients}, volume = 13, year = 2012 }