Abstract
Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
- 2,
- biological,
- biology
- calibration,
- cell
- communication,
- computer
- dynamics,
- erythropoietin,
- factor,
- janus
- kinase
- models,
- nonlinear
- receptors,
- rostock
- sbi
- signal
- simulation,
- systems
- transcription
- transduction,
- {stat5}
Users
Please
log in to take part in the discussion (add own reviews or comments).