%0 Journal Article %1 cherry2003diffusion %A Cherry, J L %A Wakeley, J %D 2003 %J Genetics %K diffusion_approximation island_model population_structure probability_of_survival %N 1 %P 421-428 %T A diffusion approximation for selection and drift in a subdivided population %U http://www.ncbi.nlm.nih.gov/pubmed/12586727 %V 163 %X The population-genetic consequences of population structure are of great interest and have been studied extensively. An area of particular interest is the interaction among population structure, natural selection, and genetic drift. At first glance, different results in this area give very different impressions of the effect of population subdivision on effective population size (N(e)), suggesting that no single value of N(e) can completely characterize a structured population. Results presented here show that a population conforming to Wright's island model of subdivision with genic selection can be related to an idealized panmictic population (a Wright-Fisher population). This equivalent panmictic population has a larger size than the actual population; i.e., N(e) is larger than the actual population size, as expected from many results for this type of population structure. The selection coefficient in the equivalent panmictic population, referred to here as the effective selection coefficient (s(e)), is smaller than the actual selection coefficient (s). This explains how the fixation probability of a selected allele can be unaffected by population subdivision despite the fact that subdivision increases N(e), for the product N(e)s(e) is not altered by subdivision.

@article{cherry2003diffusion, abstract = {The population-genetic consequences of population structure are of great interest and have been studied extensively. An area of particular interest is the interaction among population structure, natural selection, and genetic drift. At first glance, different results in this area give very different impressions of the effect of population subdivision on effective population size (N(e)), suggesting that no single value of N(e) can completely characterize a structured population. Results presented here show that a population conforming to Wright's island model of subdivision with genic selection can be related to an idealized panmictic population (a Wright-Fisher population). This equivalent panmictic population has a larger size than the actual population; i.e., N(e) is larger than the actual population size, as expected from many results for this type of population structure. The selection coefficient in the equivalent panmictic population, referred to here as the effective selection coefficient (s(e)), is smaller than the actual selection coefficient (s). This explains how the fixation probability of a selected allele can be unaffected by population subdivision despite the fact that subdivision increases N(e), for the product N(e)s(e) is not altered by subdivision.}, added-at = {2013-07-22T08:19:29.000+0200}, author = {Cherry, J L and Wakeley, J}, biburl = {https://www.bibsonomy.org/bibtex/219af2ebeabbba70f80539a8904026088/peter.ralph}, interhash = {dcf8632029ceb422965ad79f176fa12e}, intrahash = {19af2ebeabbba70f80539a8904026088}, journal = {Genetics}, keywords = {diffusion_approximation island_model population_structure probability_of_survival}, month = jan, number = 1, pages = {421-428}, pmid = {12586727}, timestamp = {2013-07-22T08:19:29.000+0200}, title = {A diffusion approximation for selection and drift in a subdivided population}, url = {http://www.ncbi.nlm.nih.gov/pubmed/12586727}, volume = 163, year = 2003 }