%0 Journal Article %1 van_alen_comparative_2010-1 %A van Alen, Tessa %A Claus, Heike %A Zahedi, René P %A Groh, Janos %A Blazyca, Heinrich %A Lappann, Martin %A Sickmann, Albert %A Vogel, Ulrich %D 2010 %J Proteomics %K Bacterial Biofilms, Mutation, Neisseria Oxygen Proteins, Proteome, Reactive Species biofilms_blebs meningitidis, %N 24 %P 4512--4521 %R 10.1002/pmic.201000267 %T Comparative proteomic analysis of biofilm and planktonic cells of Neisseria meningitidis %U http://www.ncbi.nlm.nih.gov/pubmed/21136603 %V 10 %X Neisseria meningitidis is a commensal of the human nasopharynx occasionally causing invasive disease. In vitro biofilms have been employed to model meningococcal carriage. A proteomic analysis of meningococcal biofilms was conducted and metabolic changes related to oxygen and nutrient limitation and upregulation of proteins involved in ROS defense were observed. The upregulated MntC which protects against ROS was shown to be required for meningococcal biofilm formation, but not for planktonic growth. ROS-induced proteomic changes might train the biofilm to cope with immune effectors.

@article{van_alen_comparative_2010-1, abstract = {Neisseria meningitidis is a commensal of the human nasopharynx occasionally causing invasive disease. In vitro biofilms have been employed to model meningococcal carriage. A proteomic analysis of meningococcal biofilms was conducted and metabolic changes related to oxygen and nutrient limitation and upregulation of proteins involved in {ROS} defense were observed. The upregulated {MntC} which protects against {ROS} was shown to be required for meningococcal biofilm formation, but not for planktonic growth. {ROS-induced} proteomic changes might train the biofilm to cope with immune effectors.}, added-at = {2011-06-24T11:21:47.000+0200}, author = {van Alen, Tessa and Claus, Heike and Zahedi, René P and Groh, Janos and Blazyca, Heinrich and Lappann, Martin and Sickmann, Albert and Vogel, Ulrich}, biburl = {https://www.bibsonomy.org/bibtex/2767978033b231d5ce63e62f27f153131/ag_vogel}, doi = {10.1002/pmic.201000267}, interhash = {dd7cf490754c801f172e48d2d49b0b30}, intrahash = {767978033b231d5ce63e62f27f153131}, issn = {1615-9861}, journal = {Proteomics}, keywords = {Bacterial Biofilms, Mutation, Neisseria Oxygen Proteins, Proteome, Reactive Species biofilms_blebs meningitidis,}, month = dec, note = {{PMID:} 21136603}, number = 24, pages = {4512--4521}, timestamp = {2011-06-24T16:43:35.000+0200}, title = {Comparative proteomic analysis of biofilm and planktonic cells of Neisseria meningitidis}, url = {http://www.ncbi.nlm.nih.gov/pubmed/21136603}, volume = 10, year = 2010 }