Abstract
An extensive and representative strain collection of serogroup A Neisseria meningitidis was established. These bacteria were obtained from different endemic and epidemic/pandemic sources and include strains from diseased patients and healthy carriers. The genetic relationships of the bacteria were defined by multi-locus enzyme electrophoresis and sequence polymorphisms of genetically variable antigens have been analyzed in closely-related groupings. The results are interpreted as reflecting a balance of recombination events, which disrupt clonal relationships, and sequential bottlenecks, which purify the bacterial population of genetic variants during epidemic spread.
- alleles,
- bacterial
- disease
- evolution,
- genetic
- genetic,
- humans,
- infections,
- membrane
- meningitidis,
- meningococcal
- neisseria
- outbreaks,
- outer
- porins,
- proteins,
- recombination,
- serotyping
- variation,
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