Article,

Network meta-analysis for indirect treatment comparisons.

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Statistics in medicine, 21 (16): 2313-24 (August 2002)639<m:linebreak></m:linebreak>LR: 20041117; PUBM: Print; CI: Copyright 2002; JID: 8215016; 0 (Fibrinolytic Agents); 0 (Recombinant Proteins); 133652-38-7 (reteplase); EC 3.4.21.68 (Tissue Plasminogen Activator); ppublish;<m:linebreak></m:linebreak>Network meta-analysis.
DOI: 10.1002/sim.1201

Abstract

I present methods for assessing the relative effectiveness of two treatments when they have not been compared directly in a randomized trial but have each been compared to other treatments. These network meta-analysis techniques allow estimation of both heterogeneity in the effect of any given treatment and inconsistency ('incoherence') in the evidence from different pairs of treatments. A simple estimation procedure using linear mixed models is given and used in a meta-analysis of treatments for acute myocardial infarction.

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