Abstract
Xylan is a biopolymer found in a variety of cell wall plants. Eudragit
(R) S-100 (ES100), a pH-dependent polymer, is used as a coating material
in gastroresistant delivery systems. In this study, microparticles based
on both polymers were produced by interfacial cross-linking
polymerisation and/or spray-drying technique in order to investigate
feasibility and stability of the systems. Size and morphology of the
microparticles were characterised by optical and SEM while FT-IR,
thermal analysis (TG/DTA), and X-ray diffraction (XRD) evaluated the
drug-polymer interactions and the thermal behaviour of the systems.
FT-IR confirmed the absence of chemical interaction between the
polymers. TG/DTA analysis showed a higher stability for spray-dried
microparticles and XRD data proved the amorphous feature of both
carriers. The results reveal that xylan/ES100 microparticles can be
produced by chemical or physico-mechanical ways, the latter being the
best option due to the lack of toxic cross-linking agents and easy
scale-up.
Users
Please
log in to take part in the discussion (add own reviews or comments).