%0 Journal Article %1 Hadicke2015Manipulation %A Hädicke, Oliver %A Klamt, Steffen %D 2015 %J Biochemical Society transactions %K atp cofactors metabolic-engineering %N 6 %P 1140--1145 %R 10.1042/BST20150141 %T Manipulation of the ATP pool as a tool for metabolic engineering. %U http://dx.doi.org/10.1042/BST20150141 %V 43 %X Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of ATP with a special focus on ATP wasting strategies. We discuss the importance to fine-tune the ATP yield along a production pathway to balance process performance parameters like product yield and volumetric productivity. \copyright 2015 Authors; published by Portland Press Limited.

@article{Hadicke2015Manipulation, abstract = {Cofactor engineering has been long identified as a valuable tool for metabolic engineering. Besides interventions targeting the pools of redox cofactors, many studies addressed the adenosine pools of microorganisms. In this mini-review, we discuss interventions that manipulate the availability of {ATP} with a special focus on {ATP} wasting strategies. We discuss the importance to fine-tune the {ATP} yield along a production pathway to balance process performance parameters like product yield and volumetric productivity. {\copyright} 2015 Authors; published by Portland Press Limited.}, added-at = {2018-12-02T16:09:07.000+0100}, author = {H\"{a}dicke, Oliver and Klamt, Steffen}, biburl = {https://www.bibsonomy.org/bibtex/2f1384db77426773700875fd2792349bf/karthikraman}, citeulike-article-id = {13857347}, citeulike-linkout-0 = {http://dx.doi.org/10.1042/BST20150141}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/26614651}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=26614651}, day = 1, doi = {10.1042/BST20150141}, interhash = {e9666eb4fdd934f27429fdbd0aa5503a}, intrahash = {f1384db77426773700875fd2792349bf}, issn = {1470-8752}, journal = {Biochemical Society transactions}, keywords = {atp cofactors metabolic-engineering}, month = dec, number = 6, pages = {1140--1145}, pmid = {26614651}, posted-at = {2015-12-08 06:06:10}, priority = {2}, timestamp = {2018-12-02T16:09:07.000+0100}, title = {Manipulation of the {ATP} pool as a tool for metabolic engineering.}, url = {http://dx.doi.org/10.1042/BST20150141}, volume = 43, year = 2015 }