Abstract
The polymorph selection during the discovery and development of new
drugs is a crucial factor in ensuring the efficacy of a formulation.
Thus, the physicochemical properties, including crystal structure, need
to be considered in the decision tree that leads to a drug candidate.
Riparins, natural alkamides isolated and later synthesized from Aniba
riparia, have demonstrated potential therapeutic activities in
preclinical studies, such as antidepressant, anxiolytic, and
anti-inflammatory effects. Therefore, detailed physicochemical
characterization is required as a starting point in the development of a
new formulation. This contribution aims to study the polymorphism of
three riparins, namely I, II, and III. The elucidation of the crystal
structures of several polymorphs combined with thermal analysis studies
allowed the determination of the thermodynamic relationships of the
polymorphic pairs. The solubility of the three riparins was determined
through the measurement of the corresponding dissolution profiles.
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