Article,
Preparing and Characterizing Some New Compounds of Schiff Bases Loaded on Polymers Dissolved in Water, Studying Some of their Physical Properties, And Evaluating their Biological Effectiveness
CENTRAL ASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCE, 4 (5): 45-60 (September 2023)
Abstract
This research included the preparation of Schiff bases KB7-KB11 from the reaction of 2-pyrrolidone with amines, and the compounds were identified using FT-IR spectroscopy techniques, 1H-NMR using DMSO-d6 as a solvent, SEM, and thermal analysis in addition to the melting point. This work also included studying the biological activity of some compounds prepared on two types of Gram-positive and Gram-negative bacteria, these include (Staphylococcus aureus, Klebsiella pneumonia) and Acar Mueller-Hinton culture medium. (Molar Hunting Agar) Aqueous solutions were prepared at concentrations (0.01, 0.001, 0.0001) mg/ml also using dimethyl sulfoxide (DMSO) as a solvent. The susceptibility test of the bacterial isolates used in the study was carried out by diffusion method, and the antibiotic Ampicillin was used as a control sample. The electrical conductivity and synthetic stability of some of the prepared compounds were also studied.
