Abstract
To observe therapeutic effect of acupuncture for regulating the liver
on depressive neurosis.In a multi-center randomized controlled trial,
440 patients were divided into 3 groups: Acupuncture group for regulating
the liver (Acup., 176 cases) was treated by acupuncture at Siguan
Points, i.e., bilateral Hegu (LI 4) and Taichong (LR 3), Baihui (GV
20) and Yintang (EX-HN3) plus ear-acupuncture, Prozac group (P.,
176 cases) by oral administration of Prozac, and Non-acupoint needling
group (NAN, 88 cases) by acupuncture at non-acupoints as acupuncture
placebo. Self-rating Depression Scale (SDS) was examined before treatment,
and one month, two and three months after treatment respectively
to evaluate therapeutic effect, and Rating Scale for Side Effects
(SERS) was used to evaluate the safety.After one month of treatment,
SDS scores in Acup. Group were significantly lower than that in P.
Group (P < 0.05) and than that in NAN Group (P < 0.01), and SDS scores
in P. Group were lower than that in NAN Group (P < 0.05), showing
the SDS scores in Acup. Group < P. Group < NAN Group. After 2 months
of treatment, SDS scores in Acup. Group were also significantly lower
than that in P. Group (P < 0.01) and than that in NAN Group (P <
0.01), and SDS scores in P. Group were also lower than that in NAN
Group (P < 0.05), showing the SDS scores in Acup. Group <P. Group
<NAN Group. After 3 months of treatment, SDS scores in Acup. Group
were also significantly lower than that in P. Group (P < 0.01) and
than that in NAN Group (P < 0.01), and SDS scores in P. Group were
also lower than that in NAN Group (P < 0.01), showing the SDS score
in Acup. Group < P. Group < NAN Group. After treatment, SERS scores
were 0.16 +/- 0.95, 6.51 +/- 5.09 and 0.23 +/- 1.36 in Acup. Group,
P. Group and NAN Group respectively. A significant difference existed
between Acup. Group and P. Group (P < 0.05), but no significant difference
between Acup. Group and NAN Group (P > 0.05), showing the SERS scores
in Acup. Group < NAN Group < P. Group. No side effect was found in
Acup. and NAN groups.The therapeutic effect of acupuncture on depressive
neurosis is better than or similar to that of Prozac but with less
side effect.
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