%0 Journal Article %1 Kochiadakis.2008 %A Kochiadakis, G. E. %A Marketou, M. E. %A Panutsopulos, D. %A Arfanakis, D. A. %A Skalidis, E. I. %A Igoumenidis, N. E. %A Hamilos, M. I. %A Sourvinos, G. %A Chlouverakis, G. %A Spandidos, D. %A Vardas, P. E. %D 2008 %J Eur.Heart J. %K Down-Regulation Expression Gene Monocytes Research Sirolimus Up-Regulation methods protein %N 6 %P 733-740 %T Vascular endothelial growth factor protein levels and gene expression in peripheral monocytes after stenting: a randomized comparative study of sirolimus: eluting and bare metal stents %U PM:18305085 %V 29 %X AIMS: Although previous studies have indicated that vascular endothelial growth factor (VEGF) plays an important role in the vascular-healing process after stent implantation, its effect on in-stent restenosis is unclear. We assessed VEGF serum protein levels and gene expression in peripheral monocytes in relation to in-stent restenosis after implantation of sirolimus-eluting (SES) and bare metal stents (BMS) in a non-blinded, randomized study. METHODS AND RESULTS: Forty-two patients (28 men, age 62 +/- 11 years) with stable angina, who underwent elective single-vessel percutaneous coronary intervention, were randomized to SES (n = 21) or BMS (n = 21) implantation. VEGF protein levels in the BMS group showed an increasing trend (P = 0.083), whereas in the SES group they decreased significantly (P = 0.002). BMS induced up-regulation of VEGF mRNA levels, whereas for SES down-regulation was observed. There was no correlation between serum levels and late luminal loss. A significant correl

@article{Kochiadakis.2008, abstract = {AIMS: Although previous studies have indicated that vascular endothelial growth factor (VEGF) plays an important role in the vascular-healing process after stent implantation, its effect on in-stent restenosis is unclear. We assessed VEGF serum protein levels and gene expression in peripheral monocytes in relation to in-stent restenosis after implantation of sirolimus-eluting (SES) and bare metal stents (BMS) in a non-blinded, randomized study. METHODS AND RESULTS: Forty-two patients (28 men, age 62 +/- 11 years) with stable angina, who underwent elective single-vessel percutaneous coronary intervention, were randomized to SES (n = 21) or BMS (n = 21) implantation. VEGF protein levels in the BMS group showed an increasing trend (P = 0.083), whereas in the SES group they decreased significantly (P = 0.002). BMS induced up-regulation of VEGF mRNA levels, whereas for SES down-regulation was observed. There was no correlation between serum levels and late luminal loss. A significant correl}, added-at = {2010-02-05T11:28:39.000+0100}, author = {Kochiadakis, G. E. and Marketou, M. E. and Panutsopulos, D. and Arfanakis, D. A. and Skalidis, E. I. and Igoumenidis, N. E. and Hamilos, M. I. and Sourvinos, G. and Chlouverakis, G. and Spandidos, D. and Vardas, P. E.}, biburl = {https://www.bibsonomy.org/bibtex/2191a94a2c3b18b115c91c1b38bb028c4/kanefendt}, interhash = {f3c815947499d937c4c9c849dce752c8}, intrahash = {191a94a2c3b18b115c91c1b38bb028c4}, journal = {Eur.Heart J.}, keywords = {Down-Regulation Expression Gene Monocytes Research Sirolimus Up-Regulation methods protein}, number = 6, pages = {733-740}, timestamp = {2010-02-05T11:28:49.000+0100}, title = {Vascular endothelial growth factor protein levels and gene expression in peripheral monocytes after stenting: a randomized comparative study of sirolimus: eluting and bare metal stents}, url = {PM:18305085}, volume = 29, year = 2008 }