%0 Journal Article %1 Julious2004 %A Julious, Steven A %A Patterson, Scott D %D 2004 %J Pharmaceutical Statistics %K imported %N 3 %P 213-215 %R 10.1002/pst.125 %T Sample sizes for estimation in clinical research %U http://dx.doi.org/10.1002/pst.125 http://doi.wiley.com/10.1002/pst.125 %V 3 %X A sample size justification should be given for all clinical investigations. However, sometimes the objective of a trial is to estimate an effect with a view to planning a later definitive study. This paper describes the calculations for designing studies where one wishes to adopt an estimation approach through using confidence intervals around the overall response. Calculations are given for data anticipated to take a Normal form. Copyright © 2004 John Wiley & Sons, Ltd. %@ 1539-1612

@article{Julious2004, abstract = {A sample size justification should be given for all clinical investigations. However, sometimes the objective of a trial is to estimate an effect with a view to planning a later definitive study. This paper describes the calculations for designing studies where one wishes to adopt an estimation approach through using confidence intervals around the overall response. Calculations are given for data anticipated to take a Normal form. Copyright © 2004 John Wiley & Sons, Ltd.}, added-at = {2023-02-03T11:44:35.000+0100}, author = {Julious, Steven A and Patterson, Scott D}, biburl = {https://www.bibsonomy.org/bibtex/2631f68d2ab7bf688302a70a1cc06e8d0/jepcastel}, city = {Medical Statistics Unit, Institute of General Practice and Community Care, Community Sciences Centre, Northern General Hospital, Sheffield, UK; Statistical and Data Sciences, Biomedical Data Sciences, GlaxoSmithKline Pharmaceuticals, Collegeville, PA, USA}, doi = {10.1002/pst.125}, interhash = {f4546ad2addf4e4e41527b6222c7e6f3}, intrahash = {631f68d2ab7bf688302a70a1cc06e8d0}, isbn = {1539-1612}, issn = {1539-1604}, journal = {Pharmaceutical Statistics}, keywords = {imported}, month = {7}, note = {4960<m:linebreak></m:linebreak>CP: Copyright © 2004 John Wiley &amp; Sons, Ltd.; PN: 1539-1604;<m:linebreak></m:linebreak>Sample size}, number = 3, pages = {213-215}, timestamp = {2023-02-03T11:44:35.000+0100}, title = {Sample sizes for estimation in clinical research}, url = {http://dx.doi.org/10.1002/pst.125 http://doi.wiley.com/10.1002/pst.125}, volume = 3, year = 2004 }