%0 Journal Article %1 WOS:000320632200008 %A Pinto, Nilson Vieira %A de Andrade, Nadia Ferreira %A Martinez, Diego Stefani Teodoro %A Alves, Oswaldo Luiz %A Filho, Antonio Gomes Souza %A Mota, Mario Rogerio Lima %A Nascimento, Kyria Santiago %A Cavada, Benildo Sousa %A Assreuy, Ana Maria Sampaio %C 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA %D 2013 %I AMER SCIENTIFIC PUBLISHERS %J JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY %K Acute Carbon Damage} Edema; Hyperalgesia; Infiltrate; Inflammation; Multiwalled Nanotubes; Neutrophil Paw Tissue {Oxidized %N 8 %P 5276-5282 %R 10.1166/jnn.2013.7546 %T Inflammatory and Hyperalgesic Effects of Oxidized Multi-Walled Carbon Nanotubes in Rats %V 13 %X We evaluated local inflammatory activity of oxidized multiwalled carbon nanotubes in rat experimental models of acute inflammation (paw edema and hyperalgesia) by analyzing their toxicity in non-mesoendothelial tissues. Subcutaneous injection of the nanotubes induced paw edema, that was maximal in the first 2 h after administration at 0.1 mg/kg (43.25 +/- 3.8 AUC) and 1 mg/kg (30.1 +/- 1.8 AUC) compared to saline (18.32 +/- 02.05 AUC). The histopathological analysis showed acute inflammation characterized by vasodilatation, edema formation, neutrophil infiltrate and tissue damage. The nanotubes also elicited hyperalgesic response, seen by the increase of animal paw withdrawal that was maximal in the first 3 hours. The data obtained at the 3rd h was: 75 +/- 9.3% (0.01 mg/kg), 58 +/- 8.3% (0.1 mg/kg) and 53 +/- 6.69% (1 mg/kg) in relation with saline (28 +/- 3.5%). In conclusion, the oxidized multiwalled carbon nanotubes elicit inflammatory and hyperalgesic effects associated to severe tissue damage in rats.

@article{WOS:000320632200008, abstract = {We evaluated local inflammatory activity of oxidized multiwalled carbon nanotubes in rat experimental models of acute inflammation (paw edema and hyperalgesia) by analyzing their toxicity in non-mesoendothelial tissues. Subcutaneous injection of the nanotubes induced paw edema, that was maximal in the first 2 h after administration at 0.1 mg/kg (43.25 +/- 3.8 AUC) and 1 mg/kg (30.1 +/- 1.8 AUC) compared to saline (18.32 +/- 02.05 AUC). The histopathological analysis showed acute inflammation characterized by vasodilatation, edema formation, neutrophil infiltrate and tissue damage. The nanotubes also elicited hyperalgesic response, seen by the increase of animal paw withdrawal that was maximal in the first 3 hours. The data obtained at the 3rd h was: 75 +/- 9.3% (0.01 mg/kg), 58 +/- 8.3% (0.1 mg/kg) and 53 +/- 6.69% (1 mg/kg) in relation with saline (28 +/- 3.5%). In conclusion, the oxidized multiwalled carbon nanotubes elicit inflammatory and hyperalgesic effects associated to severe tissue damage in rats.}, added-at = {2022-05-23T20:00:14.000+0200}, address = {26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA}, author = {Pinto, Nilson Vieira and de Andrade, Nadia Ferreira and Martinez, Diego Stefani Teodoro and Alves, Oswaldo Luiz and Filho, Antonio Gomes Souza and Mota, Mario Rogerio Lima and Nascimento, Kyria Santiago and Cavada, Benildo Sousa and Assreuy, Ana Maria Sampaio}, biburl = {https://www.bibsonomy.org/bibtex/2538a5999af0548d6f8cf9ee6552b6fe2/ppgfis_ufc_br}, doi = {10.1166/jnn.2013.7546}, interhash = {ff988e79465a6f7ee3c4fd2ad0af5752}, intrahash = {538a5999af0548d6f8cf9ee6552b6fe2}, issn = {1533-4880}, journal = {JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY}, keywords = {Acute Carbon Damage} Edema; Hyperalgesia; Infiltrate; Inflammation; Multiwalled Nanotubes; Neutrophil Paw Tissue {Oxidized}, number = 8, pages = {5276-5282}, publisher = {AMER SCIENTIFIC PUBLISHERS}, pubstate = {published}, timestamp = {2022-05-23T20:00:14.000+0200}, title = {Inflammatory and Hyperalgesic Effects of Oxidized Multi-Walled Carbon Nanotubes in Rats}, tppubtype = {article}, volume = 13, year = 2013 }