PyFacebook is currently best-tested with Django, and if you are just starting out with Python web development, the author highly recommends this combination :-). If you'd rather use another framework, there are also Pylons and other WSGI helpers in PyFacebook as well.
In this DigitalOcean article, we'll begin with expanding our knowledge on the excellent Gunicorn WSGI HTTP Server and continue with deploying Python WSGI web applications built atop various popular frameworks.