Depression is one of the leading contributors to the global burden of disease,1 with an increased vulnerability for women during adolescence2 and the perinatal period.3 Although former studies indicate that perinatal depression has a unique profile without history of mental health disorders,4 there is a lack of studies that prospectively and robustly examine the link between mental health before conception and subsequent perinatal mental health. To read the full article, log in using your NHS OpenAthens details