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A negative randomised sham-controlled trial of ventral capsule/ventral striatum stimulation in treatment-resistant depression: an unsuccessful trial or treatment? -- Ramasubbu 19 (2): 59 -- Evidence-Based Mental Health


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The evidence from multiple open-label trials documents the efficacy and safety of Deep brain stimulation (DBS) in the treatment of refractory depression (TRD).1 Nonetheless, randomised sham-control trials are required to determine whether the effect is directly related to active electrical stimulation or to the non-stimulation effects. To read the full article, log in using your NHS OpenAthens details

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