Cognitive impairment is a reliable feature of major depressive disorder. Depressed individuals perform more poorly than never-depressed healthy volunteers across a range of neuropsychological tests. Cognitive impairments predict poor response to antidepressant drugs, persist after successful treatment1 and are associated with poor psychosocial functioning.2 Remediation of cognitive function in depression, for example by using cognitive training strategies3 or cognitive-enhancing drugs such as modafinil,4 have been shown to boost recovery from depression. The current study aimed to test whether standard antidepressant treatment improves cognitive function in depression. To read the full article, log in using your NHS OpenAthens details.