Canadian Psychology/Psychologie canadienne58.1 (Feb 2017): 7-19. In the past 4 decades about 500 randomized trials have examined the effects of psychological treatments of adult depression. In this article the results of a series of meta-analyses of these trials are summarised. Several types of psychotherapy have been examined, including cognitive behaviour therapy, behavioural activation therapy, interpersonal psychotherapy, problem-solving therapy, nondirective supportive therapy, and short-term psychodynamic psychotherapy. All therapies are effective and there are no significant differences between treatments. Psychotherapies are about equally effective as pharmacotherapy, and combined treatments are more effective than either of these alone. Therapies are also effective in specific target groups, such as older adults, college students, patients with general medical disorders, but may be somewhat less effective in chronic depression, and in patients with comorbid substance use disorders. Treatments are effective when delivered in individual, group, and guided self-help format. The effects of psychotherapies have been overestimated because of the low quality of many trials and due to publication bias. To read the full article, log in using your NHS OpenAthens details.