%0 Journal Article %1 Jacqueline2006 %A Jacqueline, Cedric %A Caillon, Jocelyne %A Grossi, Olivier %A Le Mabecque, Virginie %A Miegeville, Anne-Françoise %A Bugnon, Denis %A Batard, Eric %A Potel, Gilles %D 2006 %J Antimicrob Agents Chemother %K endocarditis %N 7 %P 2547--2549 %R 10.1128/AAC.01501-05 %T In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus. %U http://dx.doi.org/10.1128/AAC.01501-05 %V 50 %X Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.

@article{Jacqueline2006, abstract = {Linezolid in combination with ertapenem showed in vitro synergy against methicillin-resistant Staphylococcus aureus strains. We confirmed this interaction in vivo by using a rabbit endocarditis experimental model and simulation of the human pharmacokinetics in animals for both antibiotics. Linezolid plus ertapenem exhibited highly synergistic activity in vivo after 4 days of treatment.}, added-at = {2012-02-28T22:13:56.000+0100}, author = {Jacqueline, Cedric and Caillon, Jocelyne and Grossi, Olivier and {Le Mabecque}, Virginie and Miegeville, Anne-Françoise and Bugnon, Denis and Batard, Eric and Potel, Gilles}, biburl = {https://www.bibsonomy.org/bibtex/2c1b14d769a5395cb45c96b6903336dd3/aorchid}, doi = {10.1128/AAC.01501-05}, groups = {public}, institution = {Laboratoire d'Antibiologie (UPRES EA 3826), UER de Médecine, 44035 Nantes, Cedex 01, France.}, interhash = {088301fb459eaeaa49753923c69f1692}, intrahash = {c1b14d769a5395cb45c96b6903336dd3}, journal = {Antimicrob Agents Chemother}, keywords = {endocarditis}, language = {eng}, medline-pst = {ppublish}, month = Jul, number = 7, pages = {2547--2549}, pii = {50/7/2547}, pmid = {16801442}, timestamp = {2012-02-28T22:13:56.000+0100}, title = {In vitro and in vivo assessment of linezolid combined with ertapenem: a highly synergistic combination against methicillin-resistant Staphylococcus aureus.}, url = {http://dx.doi.org/10.1128/AAC.01501-05}, username = {aorchid}, volume = 50, year = 2006 }