%0 Journal Article %1 Spinillo1997 %A Spinillo, A. %A Fazzi, E. %A Capuzzo, E. %A Stronati, M. %A Piazzi, G. %A Ferrari, A. %D 1997 %J Obstet Gynecol %K Amniotic Fluid; Cerebral Palsy; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Premature, Diseases; Logistic Models; Meconium; Prevalence; Risk Factors; Socioeconomic Factors %N 4 Pt 1 %P 519--523 %T Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants. %V 90 %X OBJECTIVE: To estimate the risk for cerebral palsy in preterm infants in relation to the presence of meconium in the amniotic fluid (AF). METHODS: A cohort study was conducted of 404 consecutive preterm infants delivered between 24 and 33 weeks' gestation at a single institution. Sociodemographic and clinical data were collected at birth. The diagnosis of cerebral palsy was made at 2 years' corrected age. Politomous logistic regression models were used to evaluate the odds for cerebral palsy while adjusting for potential confounders. RESULTS: The overall prevalence of cerebral palsy among survivors was 11.6\% (40/345). The cerebral palsy rate was 41.2\% (7/17) among infants who were meconium-stained at birth and 10\% (33/328) among those who were not (P = .006 by Fisher exact test). After adjustment for potential confounders (gestational age and fetal gender), the odds ratio of cerebral palsy among infants delivered to women with meconium-stained AF was 6.9 (95\% confidence interval 2.32, 20.81, P = .001) relative to those delivered to women with clear AF. CONCLUSION: The results of the present study support the view that the presence of meconium in the AF is a gestational age-independent risk factor for cerebral palsy among preterm infants.

@article{Spinillo1997, abstract = {OBJECTIVE: To estimate the risk for cerebral palsy in preterm infants in relation to the presence of meconium in the amniotic fluid (AF). METHODS: A cohort study was conducted of 404 consecutive preterm infants delivered between 24 and 33 weeks' gestation at a single institution. Sociodemographic and clinical data were collected at birth. The diagnosis of cerebral palsy was made at 2 years' corrected age. Politomous logistic regression models were used to evaluate the odds for cerebral palsy while adjusting for potential confounders. RESULTS: The overall prevalence of cerebral palsy among survivors was 11.6\% (40/345). The cerebral palsy rate was 41.2\% (7/17) among infants who were meconium-stained at birth and 10\% (33/328) among those who were not (P = .006 by Fisher exact test). After adjustment for potential confounders (gestational age and fetal gender), the odds ratio of cerebral palsy among infants delivered to women with meconium-stained AF was 6.9 (95\% confidence interval 2.32, 20.81, P = .001) relative to those delivered to women with clear AF. CONCLUSION: The results of the present study support the view that the presence of meconium in the AF is a gestational age-independent risk factor for cerebral palsy among preterm infants.}, added-at = {2014-07-19T21:22:55.000+0200}, author = {Spinillo, A. and Fazzi, E. and Capuzzo, E. and Stronati, M. and Piazzi, G. and Ferrari, A.}, biburl = {https://www.bibsonomy.org/bibtex/2be4ba437c283465a02ff27248de8f0ec/ar0berts}, groups = {public}, interhash = {09b35e56fa290baa4f6226ab144ee506}, intrahash = {be4ba437c283465a02ff27248de8f0ec}, journal = {Obstet Gynecol}, keywords = {Amniotic Fluid; Cerebral Palsy; Cohort Studies; Female; Gestational Age; Humans; Infant, Newborn; Premature, Diseases; Logistic Models; Meconium; Prevalence; Risk Factors; Socioeconomic Factors}, month = Oct, number = {4 Pt 1}, pages = {519--523}, pmid = {9380308}, timestamp = {2014-07-19T21:22:55.000+0200}, title = {Meconium-stained amniotic fluid and risk for cerebral palsy in preterm infants.}, username = {ar0berts}, volume = 90, year = 1997 }