%0 Journal Article %1 Desloovere2007 %A Desloovere, Kaat %A Molenaers, Guy %A Cat, Jos De %A Pauwels, Petra %A Campenhout, Anja Van %A Ortibus, Els %A Fabry, Guy %A Cock, Paul De %D 2007 %J Dev Med Child Neurol %K Botulinum Toxin Type A; Cerebral Palsy; Child; Female; Gait; Hemiplegia; Hip; Humans; Male; Motor Skills; Neuromuscular Agents; Rotation; Severity of Illness Index %N 1 %P 56--61 %R 10.1111/j.1469-8749.2007.014xa.x %T Motor function following multilevel botulinum toxin type A treatment in children with cerebral palsy. %U http://dx.doi.org/10.1111/j.1469-8749.2007.014xa.x %V 49 %X This study evaluated the effects of multilevel botulinum toxin type A (BTX-A) treatments on the gait pattern of children with spastic cerebral palsy (Gross Motor Function Classification System Levels I-III). In this nested case-control design, 30 children (mean age 6y 11mo SD 1y 5mo; 21 males, nine females; 19 with hemiplegia, 11 with diplegia) were treated according to best practice guidelines in paediatric orthopaedics, including BTX-A injections. A matched control group of 30 children (mean age 7y 8mo SD 1y 10mo; 13 males, 17 females; 19 with hemiplegia, 11 with diplegia) were treated identically, but without BTX-A. Motor development status at 5 to 10 years of age was assessed by means of three-dimensional gait analysis at a mean time of 1 year 10 months (SD 10mo) after the last BTX-A treatment. The control group showed a significantly more pronounced pathological gait pattern than the BTX-A group. Major differences were found for pelvic anterior tilt, maximum hip and knee extension, and internal hip rotation. These results provide evidence for a prolonged effect of BTX-A and suggest that BTX-A injections, in combination with common conservative treatment options, result in a gait pattern that is less defined by secondary problems (e.g. bony deformities) at 5 to 10 years of age, minimizing the need for complex surgery at a later age and enhancing quality of life.

@article{Desloovere2007, abstract = {This study evaluated the effects of multilevel botulinum toxin type A (BTX-A) treatments on the gait pattern of children with spastic cerebral palsy (Gross Motor Function Classification System Levels I-III). In this nested case-control design, 30 children (mean age 6y 11mo [SD 1y 5mo]; 21 males, nine females; 19 with hemiplegia, 11 with diplegia) were treated according to best practice guidelines in paediatric orthopaedics, including BTX-A injections. A matched control group of 30 children (mean age 7y 8mo [SD 1y 10mo]; 13 males, 17 females; 19 with hemiplegia, 11 with diplegia) were treated identically, but without BTX-A. Motor development status at 5 to 10 years of age was assessed by means of three-dimensional gait analysis at a mean time of 1 year 10 months (SD 10mo) after the last BTX-A treatment. The control group showed a significantly more pronounced pathological gait pattern than the BTX-A group. Major differences were found for pelvic anterior tilt, maximum hip and knee extension, and internal hip rotation. These results provide evidence for a prolonged effect of BTX-A and suggest that BTX-A injections, in combination with common conservative treatment options, result in a gait pattern that is less defined by secondary problems (e.g. bony deformities) at 5 to 10 years of age, minimizing the need for complex surgery at a later age and enhancing quality of life.}, added-at = {2014-07-19T19:18:50.000+0200}, author = {Desloovere, Kaat and Molenaers, Guy and Cat, Jos De and Pauwels, Petra and Campenhout, Anja Van and Ortibus, Els and Fabry, Guy and Cock, Paul De}, biburl = {https://www.bibsonomy.org/bibtex/20c239a7e1305151dd63656f901227188/ar0berts}, doi = {10.1111/j.1469-8749.2007.014xa.x}, groups = {public}, interhash = {23237ca8f1152433ceebada623a554bb}, intrahash = {0c239a7e1305151dd63656f901227188}, journal = {Dev Med Child Neurol}, keywords = {Botulinum Toxin Type A; Cerebral Palsy; Child; Female; Gait; Hemiplegia; Hip; Humans; Male; Motor Skills; Neuromuscular Agents; Rotation; Severity of Illness Index}, month = Jan, number = 1, pages = {56--61}, pii = {DMCN014xa}, pmid = {17209978}, timestamp = {2014-07-19T19:18:50.000+0200}, title = {Motor function following multilevel botulinum toxin type A treatment in children with cerebral palsy.}, url = {http://dx.doi.org/10.1111/j.1469-8749.2007.014xa.x}, username = {ar0berts}, volume = 49, year = 2007 }